Evidence map›Paper›PMID 29906338›Full record

ArticlePhysiological reports2018

A nutraceutical diet based on Lespedeza spp., Vaccinium macrocarpon and Taraxacum officinale improves spontaneous feline chronic kidney disease.

Alessandro Di Cerbo, Tommaso Iannitti, Gianandrea Guidetti, Sara Centenaro, Sergio Canello, Raffaella Cocco

Open access · goldAbstract readRandomized Controlled Trial, Veterinary
In one paragraph

Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Comparative Analysis ofMolecules (Basel, Switzerland) · 2025
    Review
  3. Review
  4. Review
  5. Nutrients · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Alessandro Di CerboDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Tommaso IannittiKWS BioTest, Portishead, Somerset, UK.
Gianandrea GuidettiResearch and Development Department, SANYpet S.p.a, Padua, Italy.
Sara CentenaroResearch and Development Department, SANYpet S.p.a, Padua, Italy.
Sergio CanelloResearch and Development Department, Forza10 USA Corp, Orlando, Florida.
Raffaella CoccoDepartment of Pathology and Veterinary Clinic, Faculty of Veterinary Medicine, University of Sassari, Sassari, Italy.
University of Padua · ITAvon and Somerset Police Authority · GBOrlando Clinical Research Center · USUniversity of Modena and Reggio Emilia · ITUniversity of Sassari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease is characterized by structural and/or functional impairment of one or both kidneys persisting for more than 3 months. In cats, chronic kidney disease can frequently occur in animals aged over 9 years with an incidence of approximately 10%. Thirty-four client-owned, neutered cats, suffering from stage II-III chronic kidney disease and diagnosed according to the International Renal Interest Society guidelines were randomly assigned to receive either a control diet (n = 17) or a nutraceutical diet (ND; n = 17) for 90 days. Both diets were commercialized for management of CKD symptoms. The diets were identical except that the ND contained tablets that consisted of 60-80% hydrolysed proteins, 20-40% minerals and active substances, that are, Lespedeza spp. 0.0588%, Vaccinium macrocarpom 0.0371%, and Taraxacum officinale 0.0231%. No adverse effects were reported during this study. Both diets resulted in an improvement in CKD symptoms. After a 90-day evaluation, creatinine, blood urea nitrogen, total proteins, and aspartate aminotransferase significantly decreased in cats that received the ND. A significant decrease was also observed in urine turbidity score, color score, and total proteins in cats that received the ND. We have found that a ND based on Lespedeza spp., Vaccinium macrocarpon, and Taraxacum officinale improves key indicators of renal failure in cats affected by chronic kidney disease.

Indexed as

Cat DiseasesDietary SupplementsRenal Insufficiency, ChronicAnimalsBody WeightCatsFemaleLespedezaMalePlant PreparationsProteinuriaTaraxacumTreatment OutcomeVaccinium macrocarponPlant PreparationsAspartate aminotransferaseblood urea nitrogencatchronic kidney diseasecreatininefelinetotal proteinsurine color scoreurine turbidity score

Identifiers

PMID29906338
PMCPMC6003637
OpenAlexW2808023080

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.