ArticleEnvironmental health perspectives2018
Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging.
Article in Environmental health perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 129 citations in OpenAlex.
- Chemical and climatic environmental exposures and epigenetic aging: A systematic review.Environmental research · 2025Pooled it
- The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial.BMC medicine · 2023Trial
- Lifestyle weight-loss intervention may attenuate methylation aging: the CENTRAL MRI randomized controlled trial.Clinical epigenetics · 2021Trial
- Sex-Specific Biological Aging-Related Lipidomic Profiles Mediate the Impact of Urinary Polycyclic Aromatic Hydrocarbon Exposures on Cognitive Function in Healthy Older Adults.Environment & health (Washington, D.C.) · 2026Article
- Occupational polycyclic aromatic hydrocarbons (PAHs) exposure is associated with accelerated aging trajectories in Chinese coke oven workers.Scientific reports · 2026Article
- Epigenome-wide association study of leukocyte telomere length and their effects on smoking-induced lung tumorigenesis: insights from the Dongfeng-Tongji cohort study.Clinical epigenetics · 2026Article
- Aging-associated ZNF573 methylation regulates RNF19B-PIK3CA ubiquitination to promote prostate cancer.Oncogene · 2025Article
- Determination of Selected Hydroxylated PAHs in Urine Samples of Individuals Consuming Grilled Marshmallows.Molecules (Basel, Switzerland) · 2025Article
- First-generation versus next-generation epigenetic aging clocks: Differences in performance and utility.Biogerontology · 2025Review
- Environmental Health Is Overlooked in Longevity Research.Antioxidants (Basel, Switzerland) · 2025Review
- Epigenetics-Based Age Acceleration Associated with 2,3,7,8 TCDD Exposure in Older Americans.International journal of molecular sciences · 2025Article
- Greater residential greenness is associated with reduced epigenetic aging in adults.Scientific reports · 2025Article
- Reduction in polycyclic aromatic hydrocarbon exposure in Beijing following China's clean air actions.Science bulletin · 2024Article
- Analyses of oxidative DNA damage among coal vendors via single cell gel electrophoresis and quantification of 8-hydroxy-2'-deoxyguanosine.Molecular and cellular biochemistry · 2024Article
- Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China.Thorax · 2024Article
- Association between single and mixed exposure to polycyclic aromatic hydrocarbons and biological aging.Frontiers in public health · 2024Article
- Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells.Epigenetics communications · 2024Article
- Household air pollution and epigenetic aging in Xuanwei, China.Environment international · 2023Article
- Dietary flavonoids intake contributes to delay biological aging process: analysis from NHANES dataset.Journal of translational medicine · 2023Article
- Healthy lifestyle, DNA methylation age acceleration, and incident risk of coronary heart disease.Clinical epigenetics · 2023Article
Corrections and comments
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Authors and funding
30 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAging is related to an increased risk of morbidity and mortality and is affected by environmental factors. Exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with adverse health outcomes; but the association of such exposure with DNA methylation aging, a novel aging marker, is unclear.
objectivesOur aim was to investigate the association of PAH exposure with methylation aging.
methodsWe trained and validated a methylation age predictor suitable for Chinese populations using whole blood methylation data in 989 Chinese and 160 Caucasians. We defined two aging indicators: δage, as methylation age minus chronological age; and aging rate, the ratio of methylation to chronological age. The association of PAH exposure with aging indicators was evaluated using linear regressions in three panels of healthy Chinese participants (
resultsWe developed a methylation age predictor providing accurate predictions in both Chinese individuals and Caucasian persons (R=0.94-0.96, RMSE=3.8-4.3). Among the 10 urinary metabolites that we measured, 1-hydroxypyrene and 9-hydroxyphenanthrene were associated with methylation aging independently of other OH-PAHs and risk factors; 1-unit increase in 1-hydroxypyrene was associated with a 0.53-y increase in Δage [95% confidence interval (CI): 0.18, 0.88; false discovery rate (FDR)
conclusionsWe developed a methylation age predictor specific for Chinese populations but also accurate for Caucasian populations. Our findings suggest that exposure to PAHs may be associated with an adverse impact on human aging and epigenetic alterations in Chinese populations. https://doi.org/10.1289/EHP2773.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.