Evidence map›Paper›PMID 29906235›Full record

ArticleThe British journal of radiology2018

Adjuvant chemoradiotherapy versus adjuvant chemotherapy for R1 resected gastric cancer: a retrospective cohort study.

Meng-Long Zhou, Gui-Chao Li, Wang Yang, Wei-Juan Deng, Ran Hu, Yan Wang, Zi-Wen Long, Xiao-Wen Liu, Ya-Nong Wang, Zhen Zhang

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. R1 Resection in Gastric Cancer: Marker of Tumor Biology Rather Than Surgical Failure.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Meng-Long Zhou1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center , Shanghai , PR China.
Gui-Chao Li1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center , Shanghai , PR China.
Wang Yang1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center , Shanghai , PR China.
Wei-Juan Deng1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center , Shanghai , PR China.
Ran Hu1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center , Shanghai , PR China.
Yan Wang1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center , Shanghai , PR China.
Zi-Wen Long2 Department of Oncology, Shanghai Medical College, Fudan University , Shanghai , PR China.
Xiao-Wen Liu2 Department of Oncology, Shanghai Medical College, Fudan University , Shanghai , PR China.
Ya-Nong Wang2 Department of Oncology, Shanghai Medical College, Fudan University , Shanghai , PR China.
Zhen Zhang1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center , Shanghai , PR China.
Shanghai Medical College of Fudan University · CNFudan University Shanghai Cancer Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to compare the effects of adjuvant chemoradiotherapy (CRT) and adjuvant chemotherapy (ChT) on the survival of locally advanced gastric cancer (LAGC) patients treated with R1 resection.

methodsThe patients with LAGC and microscopically positive margins after a potentially curative gastrectomy in Fudan University Shanghai Cancer Centre were retrospectively identified. The patients who were referred to our hospital for adjuvant CRT after an R1 resection elsewhere were also included. The patients were divided into either the CRT group or ChT group according to the treatment strategy. We, then, examined the patient survival results and patterns of recurrence for each group.

resultsThere were 114 LAGC patients treated with an R1 resection identified (CRT, n = 33; ChT, n = 81). The baseline characteristics between the two groups were not different. The estimated 3 year recurrence-free survival and overall survival in the CRT and ChT groups were 45.1% vs 31.8% (p = 0.09) and 49.6% vs 39.4% (p = 0.20), respectively. The results indicated that only nodal status was an independent prognostic factor (hazard ratio 4.04, 95% confidence interval 2.06-7.93). The risk of locoregional recurrence was increased in the ChT group. The subgroup analysis revealed that patients with pN0-2 GC showed a better recurrence-free survival due to adjuvant CRT (hazard ratio 0.19, 95% confidence interval 0.04-0.90; p = 0.022).

conclusionAdjuvant CRT improves locoregional control and may benefit patients with pN0-2 GC after R1 resection. The nodal status may be the most important predictor for patient selection. Advances in knowledge: Nodal status may be the most important predictor for patient selection. Compared with adjuvant ChT, LAGC patients with pN0-2 disease may further benefit from additional radiotherapy after R1 resection.

Indexed as

Chemoradiotherapy, AdjuvantChemotherapy, AdjuvantAnalysis of VarianceDisease-Free SurvivalFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm Recurrence, LocalPrognosisRetrospective StudiesStomach Neoplasms

Identifiers

PMID29906235
PMCPMC6223164
OpenAlexW2808083985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.