ArticleAge and ageing2018
Is frailty a stable predictor of mortality across time? Evidence from the Cognitive Function and Ageing Studies.
Article in Age and ageing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed.
- Resilience is associated with frailty and older age in hospitalised patients.BMC geriatrics · 2022Trial
- Association between cardiovascular health defined by life's essential 8 and frailty among US adults: a cross-sectional study.BMC cardiovascular disorders · 2025Article
- Predictors of progression from pre-frailty to frailty in older people: a systematic review and meta-analysis protocol.BMJ open · 2025Article
- Frailty as an independent risk factor for sepsis-associated delirium: a cohort study of 11,740 older adult ICU patients.Aging clinical and experimental research · 2025Article
- The association between reproductive factors and frailty risk: a population-based analysis from the UK biobank.BMC public health · 2025Article
- Frailty prevalence, invasive treatment frequency, and in-hospital outcome in patients hospitalized for acute coronary syndrome in Germany (2005-2022): a nationwide registry study.The Lancet regional health. Europe · 2025Article
- Creatinine-to-cystatin C ratio and frailty in older adults: a longitudinal cohort study.BMC geriatrics · 2024Article
- Secular trends in frailty among community-dwelling 75-95-year-old cohorts over three decades in Helsinki, Finland.Age and ageing · 2024Article
- Age- and sex-specific associations of frailty with mortality and healthcare utilization in community-dwelling adults from ontario, Canada.BMC geriatrics · 2024Article
- Article
- Frailty before and during austerity: A time series analysis of the English Longitudinal Study of Ageing 2002-2018.PloS one · 2024Article
- Living Longer But Frailer? Temporal Trends in Life Expectancy and Frailty in Older Swedish Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Insights into the pathological basis of dementia from population-based neuropathology studies.Neuropathology and applied neurobiology · 2023Review
- Trends in Frailty Prevalence Among Older Adults in Korea: A Nationwide Study From 2008 to 2020.Journal of Korean medical science · 2023Article
- Long-term fine particular exposure and incidence of frailty in older adults: findings from the Chinese Longitudinal Healthy Longevity Survey.Age and ageing · 2023Article
- Review
- Biomass fuel usage for cooking and frailty among older adults in China: a population-based cohort study.Frontiers in public health · 2023Article
- Trajectories, Transitions, and Trends in Frailty among Older Adults: A Review.Annals of geriatric medicine and research · 2022Article
- Relationship of body mass index with frailty and all-cause mortality among middle-aged and older adults.BMC medicine · 2022Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Background: age-specific mortality reduction has been accompanied by a decrease in the prevalence of some diseases and an increase in others. Whether populations are becoming 'healthier' depends on which aspect of health is being considered. Frailty has been proposed as an integrative measure to quantify health status. Objective: to investigate changes in the near-term lethality of frailty before and after a 20-year interval using the frailty index (FI), a summary of age-related health deficit accumulation. Design: baseline data from the Cognitive Function and Ageing Studies (CFAS) in 1991 (n = 7,635) and 2011 (n = 7,762). Setting: three geographically distinct UK centres (Newcastle, Cambridgeshire and Nottingham). Subjects: individuals aged 65 and over (both institutionalised and community-living). Methods: a 30-item frailty score was used, which includes morbidities, risk factors and subjective measures of disability. Missing items were imputed using multiple imputations by chained equations. Binomial regression was used to investigate the relationship between frailty, age, sex and cohort. Two-year mortality was modelled using logistic regression. Results: mean frailty was slightly higher in CFAS II (0.19, 95% confidence interval (CI): 0.19-0.20) than CFAS I (0.18, 95% CI: 0.17-0.18). Two-year mortality in CFAS I was higher than in CFAS II (odds ratio (OR) = 1.16, 95% CI: 1.03-1.30). The association between frailty and 2-year mortality was non-linear with an OR of ~1.6 for each 0.10 increment in the FI. Conclusions: the relationship between frailty and mortality did not significantly differ across the studies. Severe frailty as an indicator of mortality is shown to be a stable construct.
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