Evidence map›Paper›PMID 29905535›Full record

ArticleAging2018

Loss of NAMPT in aging retinal pigment epithelium reduces NAD

Ravirajsinh N Jadeja, Folami L Powell, Malita A Jones, Jasmine Fuller, Ethan Joseph, Menaka C Thounaojam, Manuela Bartoli, Pamela M Martin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Mapping the Hypoxic Fitness Landscape of Retinal Pigment Epithelial Cells.International journal of molecular sciences · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Cellular Senescence: An Emerging Player in the Pathogenesis of AMD.Advances in experimental medicine and biology · 2025
    Review
  12. Review
  13. Subcellular NADNature metabolism · 2024
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ravirajsinh N JadejaDepartment of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Folami L PowellDepartment of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Malita A JonesDepartment of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Jasmine FullerDepartment of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Ethan JosephDepartment of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Menaka C ThounaojamDepartment of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Manuela BartoliJames and Jean Culver Vision Discovery Institute, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Pamela M MartinDepartment of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Augusta University · USDiscovery Institute · US

Funding

Molecular basis of inflammation in retina, and novel strategies for limiting itR01EY022704 · NEI · AUGUSTA UNIVERSITY · PI MARTIN, PAMELA M · 2014 to 2018
$2.2M
Regulation of endogenous antioxidant systems in diabetic retinopathyR01EY022416 · NEI · AUGUSTA UNIVERSITY · PI BARTOLI, MANUELA · 2013 to 2017
$1.9M
Uric Acid and Diabetic RetinopathyR01EY028714 · NEI · AUGUSTA UNIVERSITY · PI BARTOLI, MANUELA · 2018 to 2021
$1.5M
NEI NIH HHS R01 EY022416NEI NIH HHS R01 EY022704NEI NIH HHS R01 EY028714
6 · The paper itself

Abstract

Retinal pigment epithelium (RPE) performs numerous functions critical to retinal health and visual function. RPE senescence is a hallmark of aging and degenerative retinal disease development. Here, we evaluated the temporal expression of key nicotinamide adenine dinucleotide (NAD

Indexed as

Retinal Pigment EpitheliumAcrylamidesAgingAnimalsCells, CulturedCytokinesEpithelial CellsGene Expression RegulationHumansMaleMiceNADNicotinamide MononucleotideNicotinamide PhosphoribosyltransferasePiperidinesReverse Transcriptase Polymerase Chain ReactionAcrylamidesCytokinesN-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamideNADNicotinamide MononucleotideNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humannicotinamide phosphoribosyltransferase, mousePiperidinesage-related macular degeneration (AMD)agingNAD+NAMPTretinal pigment epithelium (RPE)senescenceSIRT1

Identifiers

PMID29905535
PMCPMC6046249
OpenAlexW2807917362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.