Evidence map›Paper›PMID 29905087›Full record

ArticleTissue engineering. Part A2018

Effects of Tunable Keratin Hydrogel Erosion on Recombinant Human Bone Morphogenetic Protein 2 Release, Bioactivity, and Bone Induction.

David Joshua Cohen, Sharon L Hyzy, Salma Haque, Lucas C Olson, Barbara D Boyan, Justin M Saul, Zvi Schwartz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Natural Polymeric Scaffolds in Bone Regeneration.Frontiers in bioengineering and biotechnology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David Joshua Cohen1 Department of Biomedical Engineering, Virginia Commonwealth University , Richmond, Virginia.
Sharon L Hyzy1 Department of Biomedical Engineering, Virginia Commonwealth University , Richmond, Virginia.
Salma Haque2 Department of Chemical, Paper and Biomedical Engineering, College of Engineering and Computing, Miami University , Oxford, Ohio.
Lucas C Olson1 Department of Biomedical Engineering, Virginia Commonwealth University , Richmond, Virginia.
Barbara D Boyan1 Department of Biomedical Engineering, Virginia Commonwealth University , Richmond, Virginia.
Justin M Saul2 Department of Chemical, Paper and Biomedical Engineering, College of Engineering and Computing, Miami University , Oxford, Ohio.
Zvi Schwartz1 Department of Biomedical Engineering, Virginia Commonwealth University , Richmond, Virginia.

Funding

Keratin hydrogel matrix for tunable growth factor delivery in bone regenerationR01AR061391 · NIAMS · MIAMI UNIVERSITY OXFORD · PI SAUL, JUSTIN · 2012 to 2015
$1.4M
NIAMS NIH HHS R01 AR061391
6 · The paper itself

Abstract

impact statementRecombinant human bone morphogenetic protein 2 (rhBMP-2) delivery from collagen sponges for bone formation is an important clinical example of growth factors in tissue engineering. Side effects from rhBMP-2 burst release and rapid collagen resorption have led to investigation of alternative carriers. Here, keratin carriers with tunable erosion rates were formulated by varying disulfide crosslinking via ratios of oxidatively (keratose) to reductively (kerateine) extracted keratin. In vitro rhBMP-2 bioactivity increased with kerateine content, reaching levels greater than with collagen. Heterotopic bone formation in a mouse model depended on the keratin formulation, highlighting the importance of the growth factor carrier.

Indexed as

AnimalsBone Morphogenetic Protein 2Cell LineDelayed-Action PreparationsHumansHydrogelsKeratinsMiceOsteogenesisRecombinant ProteinsBMP2 protein, humanBone Morphogenetic Protein 2Delayed-Action PreparationsHydrogelsKeratinsRecombinant Proteinsbone morphogenetic protein 2collagendrug deliverykerateinekeratosesynthetic bone graft

Identifiers

PMID29905087
PMCPMC6238606

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.