ReviewEuropean journal of neurology2018
Antiglycine receptor antibody related disease: a case series and literature review.
Review in European journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Progressive Encephalomyelitis With Rigidity and Myoclonus With Glycine Receptor Antibodies: Clinical Features and Outcomes.Neurology(R) neuroimmunology & neuroinflammation · 2025Pooled it
- MR Imaging Findings in Anti-Leucine-Rich Glioma Inactivated Protein 1 Encephalitis: A Systematic Review and Meta-analysis.AJNR. American journal of neuroradiology · 2024Pooled it
- Cerebrospinal Fluid Findings in Patients With Autoimmune Encephalitis-A Systematic Analysis.Frontiers in neurology · 2019Pooled it
- Polyclonal glycine receptor aAbs: a challenge for personalized epitope characterization.Frontiers in molecular neuroscience · 2026Article
- Binding patterns of glycine receptor autoantibodies are related to clinical syndromes.Acta neuropathologica communications · 2025Article
- Acute neuronal cell death and neuroinflammation per se do not trigger secondary autoimmune encephalitis in mice.Scientific reports · 2025Article
- Population-Based Study of the Epidemiology of Stiff Person Syndrome in a Large Colorado-Based Health System.Neurology · 2024Article
- A Systematic Review of Sporadic Creutzfeldt-Jakob Disease: Pathogenesis, Diagnosis, and Therapeutic Attempts.Neurology international · 2024Review
- The One with Many Facets: Anti-Glycine Receptor Antibodies-Related Parkinsonism with Complex Visual Phenomena and Stiff-Limb Syndrome.Movement disorders clinical practice · 2024Article
- Clinical features in antiglycine receptor antibody-related disease: a case report and update literature review.Frontiers in immunology · 2024Review
- Brazilian autoimmune encephalitis network (BrAIN): antibody profile and clinical characteristics from a multicenter study.Frontiers in immunology · 2023Article
- The serum metabolomic profile of a distinct, inflammatory subtype of acute psychosis.Molecular psychiatry · 2022Article
- Case report: Varicella-zoster virus infection triggering progressive encephalomyelitis with rigidity and myoclonus.Frontiers in neurology · 2022Article
- Update on Paraneoplastic Cerebellar Degeneration.Brain sciences · 2021Review
- Prevalence of Neural Autoantibodies in Epilepsy of Unknown Etiology: Systematic Review and Meta-Analysis.Brain sciences · 2021Review
- Neural cell-surface and intracellular autoantibodies in patients with cognitive impairment from a memory clinic cohort.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Systemic delivery of human GlyR IgG antibody induces GlyR internalization into motor neurons of brainstem and spinal cord with motor dysfunction in mice.Neuropathology and applied neurobiology · 2021Article
- Involuntary movement in stiff-person syndrome with amphiphysin antibodies: A case report.Medicine · 2021Article
- Current Nosology of Neural Autoantibody-Associated Dementia.Frontiers in aging neuroscience · 2021Review
- Impaired Verbal Memory Recall in Patients With Axonal Degeneration and Serum Glycine-Receptor Autoantibodies-Case Series.Frontiers in psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAntibodies to glycine receptors (GlyR-Abs) were first defined in progressive encephalopathy with rigidity and myoclonus (PERM) but were subsequently identified in other clinical presentations. Our aim was to assess the clinical associations of all patients identified with GlyR-Abs in Queensland, Australia, between April 2014 and May 2017 and to compare these to cases reported in the literature.
methodsA literature review identified the clinical features of all published GlyR-Ab-positive cases through online databases. A case series was undertaken via collection of clinical information from all patients diagnosed or known to immunology, pathology or neurological services in Queensland during the study period of 3 years.
resultsIn all, 187 GlyR-Ab-positive cases were identified in the literature. The majority (47.6%) had PERM, 22.4% had epilepsy, but the remaining 30% included mixed phenotypes consisting of cerebellar ataxia, movement disorders, demyelination and encephalitis/cognitive dysfunction. By contrast, in our series of 14 cases, eight had clinical presentations consistent with seizures and epilepsy and only three cases had classical features of PERM. There was one case each of global fatiguable weakness with sustained clonus, laryngeal dystonia and movement disorder with hemiballismus and tics. The rate of response to immune therapy was similar in all groups.
conclusionAntibodies to glycine receptors are linked to a spectrum of neurological disease. The results of the literature review and our case series suggest a greater relationship between GlyR-Abs and epilepsy than previously reported.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.