ArticleBone reports2018
Spatial relationship between bone formation and mechanical stimulus within cortical bone: Combining 3D fluorochrome mapping and poroelastic finite element modelling.
Article in Bone reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 76 citations in OpenAlex.
- AI-Assisted Design and Evaluation of SLM-Ti64 Implants for Enhanced Bone Regeneration.Advanced healthcare materials · 2025Article
- Quantifying the local strain energy density distribution in the mouse tibia: the critical role of the loading direction.Biomechanics and modeling in mechanobiology · 2025Article
- Toward a clear relationship between mechanical signals and bone adaptation.Mechanobiology in medicine · 2025Review
- Mechanical deformations of bone generate interstitial fluid flow at nanoscale velocities around osteocytes.Frontiers in bioengineering and biotechnology · 2025Article
- Developing long bones respond to surrounding tissues by trans-pairing of periosteal osteoclasts and endocortical osteoblasts.Development (Cambridge, England) · 2024Article
- Cortical bone adaptation response is region specific, but not peak load dependent: insights fromBiomechanics and modeling in mechanobiology · 2024Article
- Spatial variations in the osteocyte lacuno-canalicular network density and analysis of the connectomic parameters.PloS one · 2024Article
- A novel framework for elucidating the effect of mechanical loading on the geometry of ovariectomized mouse tibiae using principal component analysis.Frontiers in bioengineering and biotechnology · 2024Article
- Derivation, validation, and prediction of loading-induced mineral apposition rates at endocortical and periosteal bone surfaces based on fluid velocity and pore pressure.Bone reports · 2023Article
- Using Finite Element Modeling in Bone Mechanoadaptation.Current osteoporosis reports · 2023Review
- Single-cell spatiotemporal analysis reveals cell fates and functions of transplanted mesenchymal stromal cells during bone repair.Stem cell reports · 2022Article
- Closing cones create conical lamellae in secondary osteonal bone.Royal Society open science · 2022Review
- Article
- A systematic review and meta-analysis on the efficacy of stem cell therapy on bone brittleness in mouse models of osteogenesis imperfecta.Bone reports · 2021Article
- Review
- The plate-to-rod transition in trabecular bone loss is elusive.Royal Society open science · 2021Article
- A Neuroskeletal Atlas: Spatial Mapping and Contextualization of Axon Subtypes Innervating the Long Bones of C3H and B6 Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Bio-Inspired Design of a Porous Resorbable Scaffold for Bone Reconstruction: A Preliminary Study.Biomimetics (Basel, Switzerland) · 2021Article
- Article
- Estimation of load conditions and strain distribution for in vivo murine tibia compression loading using experimentally informed finite element models.Journal of biomechanics · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Bone is a dynamic tissue and adapts its architecture in response to biological and mechanical factors. Here we investigate how cortical bone formation is spatially controlled by the local mechanical environment in the murine tibia axial loading model (C57BL/6). We obtained 3D locations of new bone formation by performing 'slice and view' 3D fluorochrome mapping of the entire bone and compared these sites with the regions of high fluid velocity or strain energy density estimated using a finite element model, validated with ex-vivo bone surface strain map acquired ex-vivo using digital image correlation. For the comparison, 2D maps of the average bone formation and peak mechanical stimulus on the tibial endosteal and periosteal surface across the entire cortical surface were created. Results showed that bone formed on the periosteal and endosteal surface in regions of high fluid flow. Peak strain energy density predicted only the formation of bone periosteally. Understanding how the mechanical stimuli spatially relates with regions of cortical bone formation in response to loading will eventually guide loading regime therapies to maintain or restore bone mass in specific sites in skeletal pathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.