Evidence map›Paper›PMID 29904634›Full record

ArticleFrontiers in nutrition2018

Dietary Walnuts Protect Against Obesity-Driven Intestinal Stem Cell Decline and Tumorigenesis.

Fangxia Guan, Tahmineh Tabrizian, Ardijana Novaj, Masako Nakanishi, Daniel W Rosenberg, Derek M Huffman

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fangxia GuanDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States.
Tahmineh TabrizianDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States.
Ardijana NovajDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States.
Masako NakanishiSchool of Medicine, University of Connecticut Health, Farmington, CT, United States.
Daniel W RosenbergSchool of Medicine, University of Connecticut Health, Farmington, CT, United States.
Derek M HuffmanDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States.

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Einstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HUFFMAN, DEREK MAJOR · 2010 to 2024
$10.8M
Training in Aging ResearchT32AG023475 · NIA · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI NIR J BARZILAI, DEREK Major HUFFMAN · 2004 to 2026
$8.6M
TNF alpha and IL-1 beta as pro-geronic factors in intestinal agingR56AG052981 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HUFFMAN, DEREK MAJOR · 2016 to 2016
$459k
Cell autonomous versus non-cell autonomous aging in intestinal decline and tumorigenesisR21AG055026 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HUFFMAN, DEREK MAJOR · 2017 to 2018
$459k
High-speed/resolution whole slide scanner supported by two core facilitiesS10OD019961 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI CONDEELIS, JOHN S · 2015 to 2015
$326k
NCI NIH HHS P30 CA013330NIA NIH HHS P30 AG038072NIA NIH HHS R21 AG055026NIA NIH HHS R56 AG052981NIA NIH HHS T32 AG023475NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK026687NIH HHS S10 OD019961
6 · The paper itself

Abstract

Obesity can negatively impact intestinal homeostasis, and increase colon cancer risk and related mortality. Thus, given the alarmingly high rates of obesity in the US and globally, it is critical to identify practical strategies that can break the obesity-cancer link. Walnuts have been increasingly recognized to mitigate cancer risk, and contain many bioactive constituents with antioxidant and anti-inflammatory properties that could potentially counteract pathways thought to be initiators of obesity-related cancer. Therefore, the purpose of this study was to determine if walnuts could preserve intestinal homeostasis, and attenuate tumorigenesis and growth in the context of obesity and a high calorie diet. To this end, we studied effects of walnuts on these parameters under different dietary conditions in wildtype mice, two independent

Indexed as

colon cancerinflammationintestineobesitywalnuts

Identifiers

PMID29904634
PMCPMC5990619

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.