ArticleBiomedical reports2018
Age-dependent decrease of Nurr1 protein expression in the gerbil hippocampus.
Article in Biomedical reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Effects of transient forebrain ischemia on cognitive performance and cell death in the Cornet d'Ammon 1 (CA1) region of the hippocampus in juvenile (2-month-old) and adult (6-month-old) Mongolian gerbils (Meriones unguiculatus).The Journal of veterinary medical science · 2026Article
- NURR1 expression regulates retinal pigment epithelial-mesenchymal transition and age-related macular degeneration phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Nurr1 Is Not an Essential Regulator of BDNF in Mouse Cortical Neurons.International journal of molecular sciences · 2022Article
- Comparison of age-dependent alterations in thioredoxin 2 and thioredoxin reductase 2 expressions in hippocampi between mice and rats.Laboratory animal research · 2021Article
- Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review.Frontiers in molecular neuroscience · 2021Review
- Nurr1Glia · 2020Article
- The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer's Disease-related Pathogenesis.Aging and disease · 2020Review
- Altered Nurr1 protein expression in the hippocampal CA1 region following transient global cerebral ischemia.Molecular medicine reports · 2020Article
- Wnt1 silencing enhances neurotoxicity induced by paraquat and maneb in SH-SY5Y cells.Experimental and therapeutic medicine · 2019Article
- Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death.Molecular neurobiology · 2019Review
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear receptor related-1 protein (Nurr1) serves important roles in hippocampal-dependent cognitive process. In the present study, the protein expression of Nurr1 was compared in the hippocampi of young [postnatal month 3 (PM 3)], adult (PM 12) and aged (PM 24) gerbils using western blot analysis and immunohistochemistry. Results indicated that the protein level of Nurr1 was significantly and gradually decreased in the gerbil hippocampus with increasing age. In addition, strong Nurr1 immunoreactivity was primarily observed in pyramidal neurons and granule cells of the hippocampus in the young group, which was determined to be reduced in the adult group and to a greater extent in the aged group. Collectively the data demonstrated that Nurr1 immunoreactivity was gradually and markedly decreased during normal aging. These results indicate that gradual decrease of Nurr1 expression in the hippocampus may be associated with the normal aging process and a decline in hippocampus-dependent cognitive function.
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