ArticleDermato-endocrinology2018
The rs2167270 polymorphism of leptin gene is associated with atopic dermatitis.
Article in Dermato-endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Association of leptin gene polymorphisms (rs791620 and rs7799039) with rheumatoid arthritis susceptibility and clinical manifestations: a case-control study.Clinical rheumatology · 2026Article
- Adipokines in atopic dermatitis: the link between obesity and atopic dermatitis.Lipids in health and disease · 2024Review
- Possible Role of Leptin in Atopic Dermatitis: A Literature Review.Biomolecules · 2021Review
- Leptin and the GA genotype of rs2167270 of theBiomedical reports · 2021Article
- Importance of food in the control of inflammation in atopic dermatitis.Experimental and therapeutic medicine · 2020Article
- Adipokines in the Skin and in Dermatological Diseases.International journal of molecular sciences · 2020Review
- Adipokines as Biomarkers of Atopic Dermatitis in Adults.Journal of clinical medicine · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
Atopic dermatitis is a chronic inflammatory skin disease that arises because of complex environmental, immunological, and genetic interactions. Adipokines are bioactive mediators secreted from adipocytes of white adipose tissue and are known to have a role in body metabolism and regulation of immune responses. Leptin is a proinflammatory adipokine that functions mainly to regulate food intake and energy expenditure. Few studies have implicated adipokines in the pathogenesis of atopic dermatitis. In this study, we investigated the association of three leptin gene polymorphisms: -2548G>A (rs7799039), -188 C/A (rs791620), and A19G (rs2167270), with the incidence of atopic dermatitis. One hundred and sixty-four patients and one hundred and sixty-seven age- and gender-matched controls were genotyped using the polymerase chain reaction-restriction fragment length polymorphism procedure. A significant association was found between rs2167270 and the incidence of atopic dermatitis (
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