Evidence map›Paper›PMID 29904393›Full record

ArticleJournal of functional foods2017

Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial.

Karan Agrawal, Eleni Melliou, Xueqi Li, Theresa L Pedersen, Selina C Wang, Prokopios Magiatis, John W Newman, Roberta R Holt

3 registry-linked trialsAbstract read
In one paragraph

Article in Journal of functional foods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02902913 nacompletednot on this map

Impact of Extra Virgin Olive Oil Oleocanthal Content on Platelet Reactivity in Healthy Humans

TypeinterventionalSponsorUniversity of California, DavisRan2015 to 2015Enrolled9ConditionsCardiovascular DiseasesArmsD2i2, D2i0.5, D2i0, Ibuprofen
NCT04215367 nacompletednot on this mapstarted 2018, after this paper: background citation

Effect of Dietary Intervention With High-Oleocanthal and Oleacin Extra Virgin Olive Oil in Patients With Chronic Lymphocytic Leukemia a Pilot Study

TypeinterventionalSponsorUniversity of PeloponneseRan2018 to 2019Enrolled21ConditionsChronic Lymphocytic Leukemia (CLL)ArmsHigh phenolic EVOO intake, No High phenolic EVOO intake
NCT04419948 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Acute Effect of Oleocanthal Rich Extra-virgin Olive Oil on Postpranial Hyperglycemia and Platelet Activation of T2DM Patients

TypeinterventionalSponsorHarokopio UniversityRan2019 to 2021Enrolled15ConditionsDiabetes Mellitus, Adult-Onset, Platelet Dysfunction, Postprandial Hyperglycemia, LipidemiaArmsWhite bread, Butter, Refined olive oil, EVOO with 250 mg/kg oleocanthal, EVOO with 500 mg/kg oleocanthal
3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Trial
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  15. Health Outcomes Related to the Consumption of Olive Products: A Brief Review.Plant foods for human nutrition (Dordrecht, Netherlands) · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karan AgrawalDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
Eleni MelliouDepartment of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis Zografou 15 771, Athens, Greece.
Xueqi LiUC Davis Olive Center, University of California-Davis, 392 Old Davis Road, Davis, CA 95616, USA.
Theresa L PedersenObesity and Metabolism Research Unit, USDA - Agricultural Research Service - Western Human Nutrition Research Center, 430 W Health Sciences Drive, Davis, CA 95616, USA.
Selina C WangUC Davis Olive Center, University of California-Davis, 392 Old Davis Road, Davis, CA 95616, USA.
Prokopios MagiatisDepartment of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis Zografou 15 771, Athens, Greece.
John W NewmanDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
Roberta R HoltDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.

Funding

West Coast Central Comprehensive Metabolomics Resource Core (WC3MRC)U24DK097154 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2012 to 2017
$9.9M
Training Program in Biomolecular TechnologyT32GM008799 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI LEACH, J. KENT · 2002 to 2016
$2.4M
NIDDK NIH HHS U24 DK097154NIGMS NIH HHS T32 GM008799
6 · The paper itself

Abstract

The phenolic profiles of extra virgin olive oils (EVOOs) may influence their cardiovascular benefits. In a randomized crossover of acute EVOO intake on platelet function, participants (n=9) consumed 40 mL of EVOO weekly. EVOOs were matched for total phenolic content and were either tyrosol-poor with 1:2 oleacein/oleocanthal (D2

Indexed as

extra virgin olive oilhumanoleocanthaloxylipinsplatelet aggregation

Identifiers

PMID29904393
PMCPMC5995573

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.