Evidence map›Paper›PMID 29904378›Full record

ArticleFrontiers in immunology2018

Integrin β1 Optimizes Diabetogenic T Cell Migration and Function in the Pancreas.

Gabriel Espinosa-Carrasco, Cécile Le Saout, Pierre Fontanaud, Aurélien Michau, Patrice Mollard, Javier Hernandez, Marie Schaeffer

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Barriers to immune cell infiltration in tumors.Journal for immunotherapy of cancer · 2023
    Review
  6. Transfer of mesenchymal stem cell mitochondria to CD4Stem cell research & therapy · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Gabriel Espinosa-CarrascoINSERM U1183, Institute for Regenerative Medicine and Biotherapy, University of Montpellier, Montpellier, France.
Cécile Le SaoutINSERM U1183, Institute for Regenerative Medicine and Biotherapy, University of Montpellier, Montpellier, France.
Pierre FontanaudInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.
Aurélien MichauInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.
Patrice MollardInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.
Javier HernandezINSERM U1183, Institute for Regenerative Medicine and Biotherapy, University of Montpellier, Montpellier, France.
Marie SchaefferInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.
Université de Montpellier · FRCentre National de la Recherche Scientifique · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T cell search behavior is dictated by their need to encounter their specific antigen to eliminate target cells. However, mechanisms controlling effector T cell motility are highly tissue-dependent. Specifically, how diabetogenic T cells encounter their target beta cells in dispersed islets throughout the pancreas (PA) during autoimmune diabetes remains unclear. Using intra-vital 2-photon microscopy in a mouse model of diabetes, we found that CXCR3 chemokine downregulated CD8

Indexed as

AnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell MovementCells, CulturedDiabetes Mellitus, Type 1Disease Models, AnimalFemaleHumansIntegrin beta1Intravital MicroscopyMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicCxcr3 protein, mouseIntegrin beta1Receptors, CXCR3autoimmunityimagingin vivoT cell migrationtype 1 diabetes

Identifiers

PMID29904378
PMCPMC5990596
OpenAlexW2952427366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.