Evidence map›Paper›PMID 29904359›Full record

ArticleFrontiers in psychiatry2018

Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder.

Céline S Reinbold, Andreas J Forstner, Julian Hecker, Janice M Fullerton, Per Hoffmann, Liping Hou, Urs Heilbronner, Franziska Degenhardt, Mazda Adli, Kazufumi Akiyama and 111 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

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  7. [Overexpression of miR-607 inhibits hepatocellular carcinoma cell growth and metastasis by down-regulating TRPC5].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
  8. Article
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  10. Genetic and Epigenetic Markers of Lithium Response.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

121 authors at 20 institutions in 18 countries.

Céline S ReinboldHuman Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
Andreas J ForstnerHuman Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
Julian HeckerDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Janice M FullertonNeuroscience Research Australia, Sydney, NSW, Australia.
Per HoffmannHuman Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
Liping HouIntramural Research Program, US Department of Health & Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
Urs HeilbronnerDepartment Psychiatry and Psychotherapy, Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, Germany.
Franziska DegenhardtInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Mazda AdliDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany.
Kazufumi AkiyamaDepartment of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Japan.
Nirmala AkulaIntramural Research Program, US Department of Health & Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
Raffaella ArdauUnit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy.
Bárbara AriasZoology and Biological Anthropology Section (Department of Evolutive Biology, Ecology and Environmental Sciences), Facultat de Biologia and Institut de Biomedicina, CIBERSAM, Universitat de Barcelona, Barcelona, Spain.
Lena BacklundDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Antonio BenabarreBipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, CIBERSAM, IDIBAPS, University of Barcelona, Barcelona, Spain.
Susanne BengesserSpecial Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Abesh K BhattacharjeeHealth Sciences Research, Mayo Clinic, Rochester, MN, United States.
Joanna M BiernackaDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States.
Armin BirnerSpecial Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Cynthia Marie-ClaireUniversité Paris Diderot, Sorbonne Paris Cité, UMR-S 1144, Paris, France.
Pablo CervantesThe Neuromodulation Unit, McGill University Health Centre, Montreal, QC, Canada.
Guo-Bo ChenQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Hsi-Chung ChenDepartment of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.
Caterina ChillottiUnit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy.
Scott R ClarkDiscipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.
Francesc ColomMental Health Research Group, IMIM-Hospital del Mar, Barcelona, Spain.
David A CousinsCampus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom.
Cristiana CruceanuDouglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Piotr M CzerskiPsychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
Alexandre DayerMood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.
Bruno ÉtainUniversité Paris Diderot, Sorbonne Paris Cité, UMR-S 1144, Paris, France.
Peter FalkaiDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.
Louise FrisénDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Sébastien GardService de Psychiatrie, Hôpital Charles Perrens, Bordeaux, France.
Julie S GarnhamDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, United States.
Paul GrofMood Disorders Center of Ottawa, Ottawa, ON, Canada.
Oliver GruberDepartment of Psychiatry and Psychotherapy, University Medical Center, Georg-August University Göttingen, Göttingen, Germany.
Ryota HashimotoMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.
Joanna HauserPsychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
Stefan HermsHuman Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
Stéphane JamainInstitut National de la Santé et de la Recherche Médicale U955, Psychiatrie Translationnelle, Créteil, France.
Esther JiménezBipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, CIBERSAM, IDIBAPS, University of Barcelona, Barcelona, Spain.
Jean-Pierre KahnService de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, Nancy, France.
Layla KassemIntramural Research Program, US Department of Health & Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
Sarah Kittel-SchneiderDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Sebastian KliwickiDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Barbara KönigDepartment of Psychiatry and Psychotherapeuthic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.
Ichiro KusumiDepartment of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Nina LacknerSpecial Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Gonzalo LajeIntramural Research Program, US Department of Health & Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
Mikael LandénInstitute of Neuroscience and Physiology, The Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.
Catharina LavebrattDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Marion LeboyerAssistance Publique-Hôpitaux de Paris, Hôpital Albert Chenevier - Henri Mondor, Pôle de Psychiatrie, Créteil, France.
Susan G LeckbandDepartment of Pharmacy, VA San Diego Healthcare System, San Diego, CA, United States.
Carlos A López JaramilloDepartment of Psychiatry, University of Antioquia, Medellín, Medellín, Colombia.
Glenda MacQueenDepartment of Psychiatry, University of Calgary, Calgary, AB, Canada.
Mirko ManchiaSection of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Lina MartinssonDepartment of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.
Manuel MattheisenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Michael J McCarthyDepartment of Psychiatry, VA San Diego Healthcare System, San Diego, CA, United States.
Susan L McElroyDepartment of Psychiatry, Lindner Center of Hope/University of Cincinnati, Mason, OH, United States.
Marina MitjansZoology and Biological Anthropology Section (Department of Evolutive Biology, Ecology and Environmental Sciences), Facultat de Biologia and Institut de Biomedicina, CIBERSAM, Universitat de Barcelona, Barcelona, Spain.
Francis M MondimoreDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, United States.
Palmiero MonteleoneNeurosciences Section, Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
Caroline M NievergeltHealth Sciences Research, Mayo Clinic, Rochester, MN, United States.
Urban ÖsbyDepartment of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Norio OzakiDepartment of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Roy H PerlisDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Andrea PfennigDepartment of Psychiatry and Psychotherapy, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Daniela Reich-ErkelenzDepartment Psychiatry and Psychotherapy, Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, Germany.
Guy A RouleauDepartment of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Peter R SchofieldSchool of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
K Oliver SchubertDiscipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.
Barbara W SchweizerDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, United States.
Florian SeemüllerDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.
Giovanni SeverinoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Tatyana ShekhtmanHealth Sciences Research, Mayo Clinic, Rochester, MN, United States.
Paul D ShillingHealth Sciences Research, Mayo Clinic, Rochester, MN, United States.
Kazutaka ShimodaDepartment of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan.
Christian SimhandlMedical school, Sigmund Freud University, Vienna, Austria.
Claire M SlaneyDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Jordan W SmollerDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Alessio SquassinaDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Thomas J StammDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany.
Pavla StopkovaDepartment of Psychiatry, National Institute of Mental Health, Klecany, Czechia.
Sarah K TigheDepartment of Psychiatry, University of Iowa, Iowa, IA, United States.
Alfonso TortorellaDepartment of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Gustavo TureckiDouglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Julia VolkertDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Adam J WrightSchool of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.
L Trevor YoungDepartment of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
Peter P ZandiDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
James B PotashDepartment of Psychiatry, University of Iowa, Iowa, IA, United States.
J Raymond DePauloDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, United States.
Michael BauerDepartment of Psychiatry and Psychotherapy, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Eva ReininghausSpecial Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Tomáš NovákDepartment of Psychiatry, National Institute of Mental Health, Klecany, Czechia.
Jean-Michel AubryMood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.
Mario MajDepartment of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Bernhard T BauneDiscipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.
Philip B MitchellSchool of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.
Eduard VietaBipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, CIBERSAM, IDIBAPS, University of Barcelona, Barcelona, Spain.
Mark A FryeInstitut National de la Santé et de la Recherche Médicale, U1144, Paris, France.
Janusz K RybakowskiDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Po-Hsiu KuoDepartment of Public Health and Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
Tadafumi KatoLaboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan.
Maria Grigoroiu-SerbanescuBiometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Maria Del ZompoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Frank BellivierUniversité Paris Diderot, Sorbonne Paris Cité, UMR-S 1144, Paris, France.
Martin SchallingDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Naomi R WrayQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
John R KelsoeHealth Sciences Research, Mayo Clinic, Rochester, MN, United States.
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Francis J McMahonIntramural Research Program, US Department of Health & Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
Thomas G SchulzeIntramural Research Program, US Department of Health & Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Sven CichonHuman Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
Johns Hopkins University · USMayo Clinic in Florida · USUniversity of Cagliari · ITDalhousie University · CAKarolinska Institutet · SELudwig-Maximilians-Universität München · DEMedical University of Graz · ATPoznan University of Medical Sciences · PLUniversity Hospital Frankfurt · DEUniversity of Bonn · DEInserm · FRKarolinska University Hospital · SEThe University of Adelaide · AUBlack Dog Institute · AUCentro de Investigación Biomédica en Red de Salud Mental · ESDokkyo Medical University · JPDouglas Mental Health University Institute · CAHarvard University · USMontreal Neurological Institute and Hospital · CANational Institute of Mental Health · CZ

Funding

Mapping genes that contribute to bipolar disorderZIAMH002810 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$31.2M
Medical Research Council MR/L006642/1
6 · The paper itself

Abstract

Bipolar disorder (BD) is a common, highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. Lithium is the best-established long-term treatment for BD, even though individual response is highly variable. Evidence suggests that some of this variability has a genetic basis. This is supported by the largest genome-wide association study (GWAS) of lithium response to date conducted by the International Consortium on Lithium Genetics (ConLiGen). Recently, we performed the first genome-wide analysis of the involvement of miRNAs in BD and identified nine BD-associated miRNAs. However, it is unknown whether these miRNAs are also associated with lithium response in BD. In the present study, we therefore tested whether common variants at these nine candidate miRNAs contribute to the variance in lithium response in BD. Furthermore, we systematically analyzed whether any other miRNA in the genome is implicated in the response to lithium. For this purpose, we performed gene-based tests for all known miRNA coding genes in the ConLiGen GWAS dataset (

Indexed as

bipolar disordercommon variantsgenome-wide association studylithium responsemicroRNA

Identifiers

PMID29904359
PMCPMC5991073
OpenAlexW2802899532

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.