ArticleFrontiers in aging neuroscience2018
A Larger Social Network Enhances Novel Object Location Memory and Reduces Hippocampal Microgliosis in Aged Mice.
Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Medial entorhinal-hippocampal desynchronization parallels the emergence of memory impairment in a mouse model of Alzheimer's disease pathology.Cell reports · 2026Article
- Better together than alone: sociality mitigates the negative impact of early family disruption on adult problem-solving performance in zebra finches.Proceedings. Biological sciences · 2025Article
- Individual differences in experiential diversity shape event segmentation granularity.iScience · 2025Article
- Blood predictive biomarkers for cognitive impairment among community-dwelling older adults: a cross-sectional study in China.Scientific reports · 2025Article
- Exploring the sensitivity of episodic and spatial memory tests to healthy and pathological cognitive aging.Frontiers in aging neuroscience · 2025Article
- Social enrichment on the job: Complex work with people improves episodic memory, promotes brain reserve, and reduces the risk of dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Challenges and advanced concepts for the assessment of learning and memory function in mice.Frontiers in behavioral neuroscience · 2023Review
- Pharmacological Targeting of Mitochondrial Fission and Fusion Alleviates Cognitive Impairment and Brain Pathologies in Pre-diabetic Rats.Molecular neurobiology · 2022Article
- Estimation of the density of neural, glial, and endothelial lineage cells in the adult mouse dentate gyrus.Neural regeneration research · 2022Article
- Effect of transcranial near-infrared photobiomodulation on cognitive outcomes in D-galactose/AlClLasers in medical science · 2022Article
- Social Isolation and Incident Dementia in the Oldest-Old-A Competing Risk Analysis.Frontiers in psychiatry · 2022Article
- Caloric Restriction in Group-Housed Mice: Littermate and Sex Influence on Behavioral and Hormonal Data.Frontiers in veterinary science · 2021Article
- The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2021Article
- Positive Psychosocial Factors and Cognitive Decline in Ethnically Diverse Older Adults.Journal of the International Neuropsychological Society : JINS · 2021Article
- Tau Deletion Prevents Cognitive Impairment and Mitochondrial Dysfunction Age Associated by a Mechanism Dependent on Cyclophilin-D.Frontiers in neuroscience · 2020Article
- PACAP27 mitigates an age-dependent hippocampal vulnerability to PGJ2-induced spatial learning deficits and neuroinflammation in mice.Brain and behavior · 2020Article
- Aging gracefully: social engagement joins exercise and enrichment as a key lifestyle factor in resistance to age-related cognitive decline.Neural regeneration research · 2019Review
- Enriched Physical Environment Attenuates Spatial and Social Memory Impairments of Aged Socially Isolated Mice.The international journal of neuropsychopharmacology · 2018Article
- Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget.Journal of visualized experiments : JoVE · 2018Article
- Methanolic extract ofAging · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian hippocampus shows marked decline in function with aging across many species, including humans and laboratory rodent models. This decline frequently manifests in memory impairments that occur even in the absence of dementia pathology. In humans, a number of factors correlate with preserved hippocampal memory in aging, such as exercise, cognitive stimulation and number of social ties. While interventional studies and animal models clearly indicate that exercise and cognitive stimulation lead to hippocampal preservation, there is relatively little research on whether a decline in social ties leads to cognitive decline or vice versa. Even in animal studies of environmental enrichment in aging, the focus typically falls on physical enrichment such as a rotating cast of toys, rather than the role of social interactions. The present studies investigated the hypothesis that a greater number of social ties in aging mice would lead to improved hippocampal function. Aged, female C57/Bl6 mice were housed for 3 months in pairs or large groups (7 mice per cage). Group-housed mice showed greater novel object location memory and stronger preference for a spatial navigation strategy in the Barnes maze, though no difference in escape latency, compared to pair-housed mice. Group-housed mice did not differ from pair-housed mice in basal corticosterone levels or adult hippocampal neurogenesis. Group-housed mice did, however, show reduced numbers of Iba1/CD68+ microglia in the hippocampus. These findings suggest that group housing led to better memory function and reduced markers of neuroinflammation in aged mice. More broadly, they support a causative link between social ties and hippocampal function, suggesting that merely having a larger social network can positively influence the aging brain. Future research should address the molecular mechanisms by which a greater number of social ties alters hippocampal function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.