ArticleScientific reports2018
Signature of Pareto optimization in the Escherichia coli proteome.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Design principles of the cytotoxic CD8Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Chronic pain is linked to a resting-state neural archetype that optimizes learning from punishments.bioRxiv : the preprint server for biology · 2025Article
- Tetrapod sperm length evolution in relation to body mass is shaped by multiple trade-offs.Nature communications · 2024Article
- Colloidal stability of the living cell.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Optimal Microbiome Networks: Macroecology and Criticality.Entropy (Basel, Switzerland) · 2019Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteins have coevolved with cellular environments to improve or preserve their functions, maintaining at the same time the degree of hydrophobicity necessary to fold correctly and enough solubility to perform their biological roles. Here, we study the Escherichia coli proteome using a Pareto front analysis in the solubility-hydrophobicity space. The results indicate the existence of a Pareto optimal front, a triangle whose vertices correspond to archetypal proteins specialized in distinct tasks, such as regulatory processes, membrane transport, outer-membrane pore formation, catalysis, and binding. The vertices are further enriched with proteins that occupy different subcellular compartments, namely, cytoplasmic, inner membrane, outer membrane, and outer membrane bounded periplasmic space. The combination of various enriching features offers an interpretation of how bacteria use the physico-chemical properties of proteins, both to drive them into their final destination in the cell and to have their tasks accomplished.
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