Fisher Discrimination Regularized Robust Coding Based on a Local Center for Tumor Classification.

Tumor classification is crucial to the clinical diagnosis and proper treatment of cancers. In recent years, sparse representation-based classifier (SRC) has been proposed for tumor classification. The employed dictionary plays an important role in sparse representation-based or sparse coding-based classification. However, sparse representation-based tumor classification models have not used the employed dictionary, thereby limiting their performance. Furthermore, this sparse representation model assumes that the coding residual follows a Gaussian or Laplacian distribution, which may not effectively describe the coding residual in practical tumor classification. In the present study, we formulated a novel effective cancer classification technique, namely, Fisher discrimination regularized robust coding (FDRRC), by combining the Fisher discrimination dictionary learning method with the regularized robust coding (RRC) model, which searches for a maximum a posteriori solution to coding problems by assuming that the coding residual and representation coefficient are independent and identically distributed. The proposed FDRRC model is extensively evaluated on various tumor datasets and shows superior performance compared with various state-of-the-art tumor classification methods in a variety of classification tasks.