ArticleMedical science monitor : international medical journal of experimental and clinical research2018
Anti-Vascular Endothelial Growth Factor (VEGF) Antibody Ameliorates Cartilage Degradation in a Rat Model of Chronic Sports Arthritic Injury.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Cartilage organoids: an emerging platform for novel osteoarthritis therapies.Frontiers in cell and developmental biology · 2025Review
- Targeting VEGF using Bevacizumab attenuates sepsis-induced liver injury in a mouse model of cecal ligation and puncture.Journal of medicine and life · 2023Article
- Feasibility of Growth Factor Agent Therapy in Repairing Motor Injury.Frontiers in pharmacology · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Although a relationship between vascular endothelial growth factor (VEGF) and articular cartilage degeneration has been reported, little is known regarding its role in articular cartilage injury induced by sports activities. In this study, we evaluated the role of VEGF in a rat model of chronic sports arthritic injury. MATERIAL AND METHODS Animals were divided into 3 groups: Control (n=10), Vehicle (chronic sports arthritic injury, n=10), and Bevacizumab (chronic sports arthritic injury treated with anti-VEGF monoclonal antibody Bevacizumab, n=10). RESULTS No significant difference in body weight was observed following the establishment of chronic sports arthritic injury among these 3 groups. Compared with the Vehicle group, Bevacizumab exhibited improved structure of articular cartilage (revealed by HE staining), as well as elevated cartilage content (revealed by Safranin O staining). Moreover, altered cytokines were observed after Bevacizumab treatment, indicating the significant decrease in levels of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-1, and MMP-3, and a clear increase in levels of transforming growth factor (TGF)-β1. CONCLUSIONS All these findings demonstrate that Bevacizumab treatment ameliorated cartilage degradation in rats subjected to chronic sports arthritic injury. Our results provide evidence supporting use of targeted therapy for VEGF in the clinical treatment of chronic sports arthritic injury.
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Registered trials
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