Evidence map›Paper›PMID 29903988›Full record

ReviewCancers2018

Oncolytic Viruses for Multiple Myeloma Therapy.

Christine M Calton, Kevin R Kelly, Faiz Anwer, Jennifer S Carew, Steffan T Nawrocki

Abstract readReview
In one paragraph

Review in Cancers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Comprehensive Single-Cell Immune Profiling Defines the Patient Multiple Myeloma Microenvironment Following Oncolytic Virus Therapy in a Phase Ib Trial.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Oncolytic Virotherapy and Microenvironment in Multiple Myeloma.International journal of molecular sciences · 2021
    Review
  13. Article
  14. Article
  15. Oncolytic viruses for cancer immunotherapy.Journal of hematology & oncology · 2020
    Review
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christine M CaltonDivision of Translational and Regenerative Medicine, Department of Medicine and The University of Arizona Cancer Center, Tucson, AZ 85724, USA. calton@email.arizona.edu.ORCID 0000-0002-5189-5006
Kevin R KellyJane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA. kevin.kelly@med.usc.edu.
Faiz AnwerDivision of Hematology and Oncology, University of Arizona Cancer Center, Tucson, AZ 85724, USA. anwerf@email.arizona.edu.ORCID 0000-0001-6914-7439
Jennifer S CarewDivision of Translational and Regenerative Medicine, Department of Medicine and The University of Arizona Cancer Center, Tucson, AZ 85724, USA. jcarew@email.arizona.edu.
Steffan T NawrockiDivision of Translational and Regenerative Medicine, Department of Medicine and The University of Arizona Cancer Center, Tucson, AZ 85724, USA. snawrocki@email.arizona.edu.

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
Endoplasmic reticulum stress and oncoviral therapyR01CA190789 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI NAWROCKI, STEFFAN T · 2015 to 2020
$1.6M
Development of lysosome targeted therapeuticsR41CA271967 · NCI · MAJESTIC THERAPEUTICS, LLC · PI CAREW, JENNIFER S, NAWROCKI, STEFFAN T · 2022 to 2022
$258k
NCI NIH HHS P30 CA023074NCI NIH HHS R01 CA190789NCI NIH HHS R41 CA271967
6 · The paper itself

Abstract

Although recent treatment advances have improved outcomes for patients with multiple myeloma (MM), the disease frequently becomes refractory to current therapies. MM thus remains incurable for most patients and new therapies are urgently needed. Oncolytic viruses are a promising new class of therapeutics that provide tumor-targeted therapy by specifically infecting and replicating within cancerous cells. Oncolytic therapy yields results from both direct killing of malignant cells and induction of an anti-tumor immune response. In this review, we will describe oncolytic viruses that are being tested for MM therapy with a focus on those agents that have advanced into clinical trials.

Indexed as

adenovirusmeasles virusmultiple myelomamyxoma virusoncolytic virotherapyreovirusvaccinia virusvesicular stomatitis virus

Identifiers

PMID29903988
PMCPMC6025383

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.