Evidence map›Paper›PMID 29903983›Full record

ArticleMolecules (Basel, Switzerland)2018

4'-Methoxyresveratrol Alleviated AGE-Induced Inflammation via RAGE-Mediated NF-κB and NLRP3 Inflammasome Pathway.

Wenzhe Yu, Mengru Tao, Yueliang Zhao, Xiaoqian Hu, Mingfu Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Review
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  6. [Gandou Bushen decoction ameliorates ovarian injury in murine hepatolenticular degeneration via the AGE/RAGE/NF-κB signaling pathway].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Article
  7. Article
  8. Review
  9. Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  10. Review
  11. Article
  12. Antimicrobial Peptide Signaling in Skin Diseases.JID innovations : skin science from molecules to population health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Wenzhe YuCollege of Food Science and Technology, Shanghai Ocean University, No. 999 Hu Cheng Huan Road, LinGang New City, Shanghai 201306, China. wzyu0129@outlook.com.
Mengru TaoCollege of Food Science and Technology, Shanghai Ocean University, No. 999 Hu Cheng Huan Road, LinGang New City, Shanghai 201306, China. tmemory139@163.com.
Yueliang ZhaoCollege of Food Science and Technology, Shanghai Ocean University, No. 999 Hu Cheng Huan Road, LinGang New City, Shanghai 201306, China. ylzhao@shou.edu.cn.
Xiaoqian HuCollege of Food Science and Technology, Shanghai Ocean University, No. 999 Hu Cheng Huan Road, LinGang New City, Shanghai 201306, China. xqhu@shou.edu.cn.
Mingfu WangCollege of Food Science and Technology, Shanghai Ocean University, No. 999 Hu Cheng Huan Road, LinGang New City, Shanghai 201306, China. mfwang@shou.edu.cn.
Shanghai Ocean University · CNUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced glycation end products (AGEs) could interact with the receptor for AGE (RAGE) as a sterile danger signal to induce inflammation. 4′-methoxyresveratrol (4′MR), a polyphenol derived from Dipterocarpaceae, has not been studied for its anti-inflammation effects. In the present study, we sought to explore the protective role of 4′MR in AGEs-induced inflammatory model using RAW264.7 macrophages. 4′MR significantly inhibited gene expression of pro-inflammatory cytokines and chemokines, such as interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α) and monocyte chemoattractant protein-1 (MCP-1), as well as two typical pro-inflammatory enzymes, inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2). Besides, 4′MR significantly decreased oxidative stress, demonstrated by levels of ROS production, protein carbonyl and advanced oxidation protein product via down-regulation of NADPH oxidase. Further analysis showed that 4′MR attenuated the RAGE overexpression induced by MGO-BSA. It also blocked the downstream signal of AGE-RAGE, particularly, MAPKs including p38 and JNK, and subsequently reduced NF-κB activation. Additionally, 4′MR significantly abated the activation of NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome including NLRP3 and cleaved caspase-1 and reduced the secretion of mature IL-1β. Taken together, our results suggest that the anti-inflammatory effect of 4′MR is mainly through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation. 4′MR could be a novel therapeutic agent for inflammation-related diseases.

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalCytokinesDipterocarpaceaeGene Expression RegulationGlycation End Products, AdvancedMiceNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinOxidative StressPlant ExtractsPolyphenolsRAW 264.7 CellsReceptor for Advanced Glycation End ProductsResveratrolSignal Transduction4'-methoxyresveratrolAger protein, mouseAnti-Inflammatory Agents, Non-SteroidalCytokinesGlycation End Products, AdvancedNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousePlant ExtractsPolyphenolsReceptor for Advanced Glycation End ProductsResveratrolStilbenes4′-methoxyresveratrolMAPKNF-κBNLRP3 inflammasomeoxidative stressRAGE

Identifiers

PMID29903983
PMCPMC6100160
OpenAlexW2808181572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.