ArticleCancer discovery2018
Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins.
Open access · bronzeAbstract read
In one paragraph
Article in Cancer discovery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 246 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
246citing papers in PubMed, 1 pooled it
11.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
246 citing papers in PubMed, 1 synthesis or guideline pooled it, 347 citations in OpenAlex.
- The role of lipid metabolic reprogramming in tumor microenvironment.Theranostics · 2023Pooled it
- MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming.Cell cycle (Georgetown, Tex.) · 2026Review
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- CDS2 Drives Tumor Progression in Epithelial Ovarian Cancer via the PI3K/AKT Pathway.Cancer medicine · 2026Article
- Cancer-associated adipocytes: metabolic reprogramming, crosstalk and therapeutic implications in tumor progression.Signal transduction and targeted therapy · 2026Review
- CEBPG-Mediated Palmitic Acid Adaptation of Cancer-Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- SUMOylation-Driven Subtype Heterogeneity and Prognostic Biomarkers in Renal Cell Carcinoma.Current issues in molecular biology · 2026Article
- Light-driven thermotropic hydrogel with nanomodulator enables lipid intervention and cavity delivery for postsurgical tumor therapy.Cell reports. Medicine · 2026Article
- Mechanistic Links Between Obesity and Breast Cancer Progression: Cellular Crosstalk, Metabolic Reprogramming and Microenvironmental Drivers.Cell biochemistry and function · 2026Review
- LncRNA NRAV is associated with unfavorable prognosis and immune-related transcriptional features in hepatocellular carcinoma.Discover oncology · 2026Article
- SLC27A1 overexpression correlates with lactylation and poor colorectal cancer progression.Scientific reports · 2026Article
- Fatty acid metabolic reprogramming in the tumor microenvironment: Unraveling mechanisms and therapeutic prospects.Genes & diseases · 2026Review
- Lipid metabolism as a central driver of immune remodeling and therapeutic vulnerability in metastatic colorectal cancer.Lipids in health and disease · 2026Review
- Uncovering the Intricate and Heterogeneous Cellular Microenvironment of Cutaneous Melanoma.Medicina (Kaunas, Lithuania) · 2026Review
- Fatty acid transporter protein isoform 2 (FATP2) inhibitor lipofermata inhibits Zika virus replication and blocks fatty acid uptake in SH-SY5Y neuroblastoma cell line.Microbiology spectrum · 2026Article
- Large adipocytes increase vesicle-mediated lipid release and promote breast cancer malignancy.Cell reports · 2026Article
- Obesity and melanoma: unraveling the paradoxical survival benefit in immunotherapy.Cancer metastasis reviews · 2026Review
- Adipocyte-Derived Extracellular Vesicles Endow Melanoma Cells with Stem-like Traits via PGC-1α-Mediated Mitochondrial Reprogramming.Antioxidants (Basel, Switzerland) · 2026Article
- Metabolic crosstalk among cancer-associated fibroblasts, adipocytes and immune cells as an immunosuppressive tumor microenvironment driver.Experimental & molecular medicine · 2026Review
186 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
22 authors at 5 institutions in 1 country.
Maomao ZhangDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.
Julie S Di MartinoDepartment of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine, Tisch Cancer Institute at Mount Sinai, New York, New York.
Robert L BowmanDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.
Nathaniel R CampbellDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-0355-0708
Sanjeethan C BakshWeill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, New York.
Theresa Simon-VermotDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.
Isabella S KimDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.
Pearce HaldemanDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.
Chandrani MondalDepartment of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine, Tisch Cancer Institute at Mount Sinai, New York, New York.
Vladimir Yong-GonzalesMarron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, New York.
Mohsen Abu-AkeelImmunology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Taha MerghoubImmunology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Drew R JonesMetabolomics Core Resource Library, New York University Langone Health, New York, New York.
Xiphias Ge ZhuLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, New York.
Arshi AroraDepartment of Epidemiology-Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Charlotte E AriyanDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Kivanç BirsoyLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, New York.
Jedd D WolchokImmunology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Katherine S PanageasDepartment of Epidemiology-Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Travis HollmannDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Jose Javier Bravo-CorderoDepartment of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine, Tisch Cancer Institute at Mount Sinai, New York, New York.
Richard M WhiteDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York. whiter@mskcc.org.
Memorial Sloan Kettering Cancer Center · USTisch Hospital · USRockefeller University · USCornell University · USNYU Langone Health · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MWeill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1MTHE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Deanna L Benson · 2015 to 2026
$35.4MEvolutionary dynamics of melanoma metastasisDP2CA186572 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI WHITE, RICHARD MARK · 2013 to 2013
$2.7MThe role of melanocyte precursors in zebrafish pigmentation disordersK08AR055368 · NIAMS · SLOAN-KETTERING INST CAN RESEARCH · PI WHITE, RICHARD MARK · 2009 to 2013
$635kProtrusion plasticity during in vivo tumor cell migrationK22CA196750 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BRAVO-CORDERO, JOSE JAVIER · 2016 to 2018
$577kDissecting the Ecology of Metastasis in a Zebrafish Model: Trade-Offs of Size and Diversity in Circulating Tumor Cell ClustersF30CA220954 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CAMPBELL, NATHANIEL R · 2018 to 2021
$194kThe role of adipocytes in melanomaF32CA210536 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ZHANG, XIANG · 2017 to 2018
$118kNCI NIH HHS DP2 CA186572NCI NIH HHS F30 CA220954NCI NIH HHS F32 CA210536NCI NIH HHS K22 CA196750NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA196521NIAMS NIH HHS K08 AR055368NIGMS NIH HHS T32 GM007739
Abstract
Advanced, metastatic melanomas frequently grow in subcutaneous tissues and portend a poor prognosis. Though subcutaneous tissues are largely composed of adipocytes, the mechanisms by which adipocytes influence melanoma are poorly understood. Using
Indexed as
3T3-L1 CellsAdipocytesAnimalsAnimals, Genetically ModifiedBiological TransportCell Line, TumorCell MovementCell ProliferationCoculture TechniquesDisease ProgressionFatty AcidsFatty Acid Transport ProteinsGene Expression Regulation, NeoplasticHumansMelanomaMice5'-bromo-5-phenyl-spiro(3H-1,3,4-thiadiazole-2,3'-indoline)-2'-oneBRAF protein, humanFatty AcidsFatty Acid Transport ProteinsProto-Oncogene Proteins B-rafSLC27A1 protein, humanSpiro CompoundsThiadiazoles
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