Evidence map›Paper›PMID 29903854›Full record

ArticleJournal of medical ethics2018

Development of a consensus approach for return of pathology incidental findings in the Genotype-Tissue Expression (GTEx) project.

Nicole C Lockhart, Carol J Weil, Latarsha J Carithers, Susan E Koester, A Roger Little, Simona Volpi, Helen M Moore, Benjamin E Berkman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical ethics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nicole C LockhartDivision of Genomics and Society, National Human Genome Research Institute, National Institutes of Health, Rockville, Maryland, USA.
Carol J WeilDivision of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Latarsha J CarithersDivision of Extramural Activities, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
Susan E KoesterDivision of Neuroscience and Basic Behavioral Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
A Roger LittleDivision of Neuroscience and Behavior, National Institute on Drug Abuse, National Institutes of Health, Rockville, Maryland, USA.
Simona VolpiDivision of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Helen M MooreDivision of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Benjamin E BerkmanDepartment of Bioethics, National Institutes of Health Bioethics Core, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
National Institutes of Health · US

Funding

CCR NIH HHS HHSN261200800001CIntramural NIH HHS Z99 HG999999NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

The active debate about the return of incidental or secondary findings in research has primarily focused on return to research participants, or in some cases, family members. Particular attention has been paid to return of genomic findings. Yet, research may generate other types of findings that warrant consideration for return, including findings related to the pathology of donated biospecimens. In the case of deceased biospecimen donors who are also organ and/or tissue transplant donors, pathology incidental findings may be relevant not to family members, but to potential organ or tissue transplant recipients. This paper will describe the ethical implications of pathology incidental findings in the Genotype-Tissue Expression (GTEx) project, the process for developing a consensus approach as to if/when such findings should be returned, possible implications for other research projects collecting postmortem tissues and how the scenario encountered in GTEx fits into the larger return of results/incidental findings debate.

Indexed as

Incidental FindingsTransplant RecipientsConfidentialityDisclosureGenomicsHumansPathologyclinical ethicsdonation/procurement of organs/tissueshuman tissuepathologyresearch ethics

Identifiers

PMID29903854
PMCPMC6740237
OpenAlexW2807811221

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.