Evidence map›Paper›PMID 29903785›Full record

Trial reportBMJ open2018

Cost-effectiveness analysis of internet-mediated cognitive behavioural therapy for depression in the primary care setting: results based on a controlled trial.

Anna Holst, Cecilia Björkelund, Alexandra Metsini, Jens-Henrik Madsen, Dominique Hange, Eva-Lisa L Petersson, Maria Cm Eriksson, Marie Kivi, Per-Åke Å Andersson, Mikael Svensson

Open access · goldAbstract readMulticenter StudyPragmatic Clinical Trial
In one paragraph

Trial report in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 6 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 6 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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  5. Digital interventions in mental health: evidence syntheses and economic modelling.Health technology assessment (Winchester, England) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Anna HolstDepartment of Primary Health Care/Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-5083-3970
Cecilia BjörkelundDepartment of Primary Health Care/Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0003-4083-7342
Alexandra MetsiniCounty Council of Värmland, Karlstad, Sweden.
Jens-Henrik MadsenDept of Economics and IT, University West, Trollhättan, Sweden.
Dominique HangeDepartment of Primary Health Care/Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Eva-Lisa L PeterssonDepartment of Primary Health Care/Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Maria Cm ErikssonDepartment of Primary Health Care/Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Marie KiviDepartment of Psychology, University of Gothenburg, Gothenburg, Sweden.
Per-Åke Å AnderssonDepartment of Economics, School of Business, Economics and Law at University of Gothenburg, Gothenburg, Sweden.
Mikael SvenssonDepartment of Health Metrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
University of Gothenburg · SECounty Administrative Board · SERegion Västra Götaland · SEUniversity West · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo perform a cost-effectiveness analysis of a randomised controlled trial of internet-mediated cognitive behavioural therapy (ICBT) compared with treatment as usual (TaU) for patients with mild to moderate depression in the Swedish primary care setting. In particular, the objective was to assess from a healthcare and societal perspective the incremental cost-effectiveness ratio (ICER) of ICBT versus TaU at 12 months follow-up.

designA cost-effectiveness analysis alongside a pragmatic effectiveness trial.

settingSixteen primary care centres (PCCs) in south-west Sweden.

participantsNinety patients diagnosed with mild to moderate depression at the PCCs.

main outcome measureICERs calculated as (Cost

resultsThe total cost per patient for ICBT was 4044 Swedish kronor (SEK) (€426) (healthcare perspective) and SEK47 679 (€5028) (societal perspective). The total cost per patient for TaU was SEK4434 (€468) and SEK50 343 (€5308). In both groups, the largest cost was associated with productivity loss. The differences in cost per patient were not statistically significant. The mean reduction in BDI-II score was 13.4 and 13.8 units in the ICBT and TaU groups, respectively. The mean QALYs per patient was 0.74 and 0.79 in the ICBT and TaU groups, respectively. The differences in BDI-II score reduction and mean QALYs were not statistically significant. The uncertainty of the study estimates when assessed by bootstrapping indicated that no firm conclusion could be drawn as to whether ICBT treatment compared with TaU was the most cost-effective use of resources.

conclusionsICBT was regarded to be as cost-effective as TaU as costs, health outcomes and cost-effectiveness were similar for ICBT and TaU, both from a healthcare and societal perspective. TRIAL REGISTRATION NUMBER: ID NR 30511.

Indexed as

InternetAdultCognitive Behavioral TherapyCost-Benefit AnalysisDepressive DisorderFemaleHumansMaleMiddle AgedPrimary Health CarePsychiatric Status Rating ScalesQuality-Adjusted Life YearsSwedenTreatment Outcomecost-effectivenessicbtinternet mediated cognitive behavioural therapyprimary careSweden

Identifiers

PMID29903785
PMCPMC6009451
OpenAlexW2808328353

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.