Evidence map›Paper›PMID 29903766›Full record

ArticleHaematologica2018

Cytoprotective and pro-angiogenic functions of thrombomodulin are preserved in the C loop of the fifth epidermal growth factor-like domain.

Xiangmin Wang, Bin Pan, Goichi Honda, Xintao Wang, Yuko Hashimoto, Hiroshi Ohkawara, Kailin Xu, Lingyu Zeng, Takayuki Ikezoe

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. The Role of GPR15 Function in Blood and Vasculature.International journal of molecular sciences · 2021
    Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Xiangmin WangDepartment of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Bin PanDepartment of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Goichi HondaMedical Affairs Department, Asahi Kasei Pharma, Kanda Jinbocho, Chiyoda-ku, Tokyo, Japan.
Xintao WangDepartment of Hematology, Fukushima Medical University, Japan.
Yuko HashimotoDepartment of Diagnostic Pathology, Fukushima Medical University, Japan.
Hiroshi OhkawaraDepartment of Hematology, Fukushima Medical University, Japan.
Kailin XuDepartment of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Lingyu ZengDepartment of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China ikezoet@fmu.ac.jp zengly2000@163.com.
Takayuki IkezoeDepartment of Hematology, Fukushima Medical University, Japan ikezoet@fmu.ac.jp zengly2000@163.com.
Fukushima Medical University · JPXuzhou Medical College · CNAsahi Kasei (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously found that the fifth epidermal growth factor-like domain of thrombomodulin (TME5) exerts cytoprotective and pro-angiogenic functions

Indexed as

Angiogenesis Inducing AgentsApoptosisCytoprotectionNeovascularization, PhysiologicThrombomodulinAnimalsHumansHuman Umbilical Vein Endothelial CellsMiceProtein DomainsProtein Structure, SecondaryAngiogenesis Inducing AgentsTHBD protein, humanThrombomodulin

Identifiers

PMID29903766
PMCPMC6165823
OpenAlexW2808696036

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.