SynthesisJournal of the American Society of Nephrology : JASN2018
Transethnic, Genome-Wide Analysis Reveals Immune-Related Risk Alleles and Phenotypic Correlates in Pediatric Steroid-Sensitive Nephrotic Syndrome.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome.Nature communications · 2023Pooled it
- Estimation of childhood nephrotic syndrome incidence: data from the atlanta metropolitan statistical area and meta-analysis of worldwide cases.Journal of nephrology · 2022Pooled it
- Proteome-wide Mendelian randomization identifies APOM and TNXB as actionable mediators of steroid-sensitive nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2026Article
- Novel immune-related susceptibility loci associated with pediatric steroid-sensitive nephrotic syndrome identified by a transethnic genome-wide association study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Article
- Aligning Practice With Guidelines: A Canadian National Survey and Canadian Society of Nephrology Commentary on the 2025 KDIGO Pediatric Nephrotic Syndrome Recommendations.Canadian journal of kidney health and disease · 2026Article
- Opportunities and challenges in recurrent diffuse podocytopathy post-transplantation: the critical value of the definition.Frontiers in immunology · 2026Review
- Etiology of nephrotic syndrome: insights from univariate and multivariate Mendelian randomization study.Renal failure · 2025Article
- Uncommon Factors Leading to Nephrotic Syndrome.Biomedicines · 2025Review
- Genetic aspects of pediatric nephrotic syndrome and anti-nephrin antibodies.Clinical and experimental nephrology · 2025Review
- MicroRNAs in idiopathic childhood nephrotic syndrome.Clinical and experimental nephrology · 2025Article
- Post-transplant glomerular diseases: update on pathophysiology, risk factors and management strategies.Clinical kidney journal · 2024Review
- Pediatric contributions and lessons learned from the NEPTUNE cohort study.Pediatric nephrology (Berlin, Germany) · 2024Review
- A genomic association study revealing subphenotypes of childhood steroid-sensitive nephrotic syndrome in a larger genomic sequencing cohort.Genes & diseases · 2024Article
- Common Risk Variants inKidney international reports · 2023Article
- Hiding in plain sight: genetics of childhood steroid-resistant nephrotic syndrome in Sub-Saharan Africa.Pediatric nephrology (Berlin, Germany) · 2023Review
- Shared genetic risk across different presentations of gene test-negative idiopathic nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2023Article
- T-cell receptor diversity in minimal change disease in the NEPTUNE study.Pediatric nephrology (Berlin, Germany) · 2023Article
- State of the art in childhood nephrotic syndrome: concrete discoveries and unmet needs.Frontiers in immunology · 2023Review
- Genetic risk variants for childhood nephrotic syndrome and corticosteroid response.Frontiers in pediatrics · 2023Article
- The role of HLA antigens in recurrent primary focal segmental glomerulosclerosis.Frontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
22 authors at 13 institutions in 5 countries.
Hanna DebiecSorbonne Université, UPMC Paris 06, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche S 1155, Paris, France.
Claire DossierDepartment of Paediatric Nephrology and.
Eric LetouzéPediatric Pharmacology and Pharmacogenetics, CIC1426, Hôpital Robert Debré, Paris, France.
Christopher E GilliesPediatric Nephrology, University of Michigan School of Medicine, Ann Arbor, Michigan.
Marina VivarelliNephrology and Dialysis Department, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Rosemary K PutlerPediatric Nephrology, University of Michigan School of Medicine, Ann Arbor, Michigan.
Elisabet ArsMolecular Biology Laboratory, Fundació Puigvert, Instituto de Investigaciones Biomédicas Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Evelyne Jacqz-AigrainPediatric Pharmacology and Pharmacogenetics, CIC1426, Hôpital Robert Debré, Paris, France.
Valery EliePediatric Pharmacology and Pharmacogenetics, CIC1426, Hôpital Robert Debré, Paris, France.
Manuela ColucciNephrology and Dialysis Department, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Stéphanie DebetteUniversity of Bordeaux, Institut National de la Santé et de la Recherche Médicale, Bordeaux Population Health Research Center, Unité Mixte de Recherche 1219, CHU Bordeaux, Bordeaux, France.
Philippe AmouyelUniversity of Lille, Institut National de la Santé et de la Recherche Médicale, CHU Lille, Institut Pasteur de Lille, U1167 RID-AGE, Lille, France.
Siham C ElalaouiDepartment of Medical Genetics, Institut National d'Hygiène, Rabat, Morocco.
Abdelaziz SefianiHuman Genomic Center, Faculté de Médecine et de Pharmacie Rabat, Université Mohamed V. Rabat, Rabat, Morocco.
Valérie DuboisEtablissement Français du Sang Rhone-Alpes, Lyon, Rhone-Alpes, France.
Tabassome SimonAssistance Publique-Hôpitaux de Paris, Hôpital Saint Antoine, Department of Clinical Pharmacology, Unité de Recherche Clinique, Paris, France.
Matthias KretzlerDepartment of Internal Medicine and Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan; mgsamps@med.umich.edu georges.deschenes@aphp.fr pierreronco@yahoo.fr.ORCID 0000-0003-4064-0582
Jose BallarinDepartment of Nephrology, Fundación Puigvert, Barcelona, Spain.
Francesco EmmaPediatric Nephrology, University of Michigan School of Medicine, Ann Arbor, Michigan.
Matthew G SampsonPediatric Nephrology, University of Michigan School of Medicine, Ann Arbor, Michigan; mgsamps@med.umich.edu georges.deschenes@aphp.fr pierreronco@yahoo.fr.ORCID 0000-0001-9560-076X
Georges DeschênesDepartment of Paediatric Nephrology and mgsamps@med.umich.edu georges.deschenes@aphp.fr pierreronco@yahoo.fr.
Pierre RoncoSorbonne Université, UPMC Paris 06, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche S 1155, Paris, France; mgsamps@med.umich.edu georges.deschenes@aphp.fr pierreronco@yahoo.fr.ORCID 0000-0002-0280-6900
Inserm · FRMichigan Medicine · USBambino Gesù Children's Hospital · ITHôpital Robert-Debré · FRÉtablissement Français du Sang · FRInstitut National d'Hygiène du Maroc · MAMohammed V University · MAPuigvert Foundation · ESUniversitat Autònoma de Barcelona · ESUniversité de Bordeaux · FRUniversité de Lille · FRUniversité Paris Cité · FRUniversity of Michigan · US
Funding
Training Program in Clinical & Translationa Research in Human Glomerular DiseaseU54DK083912 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLZMAN, LAWRENCE B. · 2009 to 2023
$20.3MAPOL1 - associated nephropathy from human-derived, intrarenal perspectiveR01DK108805 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MATTHEW Gordon SAMPSON, Simone Sanna-Cherchi · 2016 to 2026
$3.4MNIDDK NIH HHS R01 DK108805NIDDK NIH HHS U54 DK083912
Abstract
PubMed holds no abstract for this paper.
Indexed as
Africa, NorthernAllelesBlack PeopleButyrophilinsCase-Control StudiesChildChild, PreschoolCohort StudiesFemaleFranceGenome-Wide Association StudyHLA-DQ AntigensHLA-DQ beta-ChainsHLA-DR AntigensHLA-DRB1 ChainsHLA-DRB5 ChainsBTNL2 protein, humanButyrophilinsHLA-DQ AntigensHLA-DQB1 antigenHLA-DQ beta-ChainsHLA-DR AntigensHLA-DRB1 ChainsHLA-DRB5 ChainsSteroidsfocal segmental glomerulosclerosisgene expressiongenetic renal diseasegenome-wide association studynephrotic syndromepediatrics
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What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.