Evidence map›Paper›PMID 29903735›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2018

Impact of Gut Microbiota and Diet on the Development of Atherosclerosis in Apoe

Annika Lindskog Jonsson, Robert Caesar, Rozita Akrami, Christoph Reinhardt, Frida Fåk Hållenius, Jan Borén, Fredrik Bäckhed

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 149 citations in OpenAlex.

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  8. The gut microbiota in thrombosis.Nature reviews. Cardiology · 2025
    Review
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  13. Gut microbiota and atrial cardiomyopathy.Frontiers in cardiovascular medicine · 2025
    Review
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  18. Article
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Annika Lindskog JonssonFrom the Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Sahlgrenska University Hospital, University of Gothenburg, Sweden (A.L.J., R.C., R.A., C.R., F.F.H., J.B., F.B.).
Robert CaesarFrom the Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Sahlgrenska University Hospital, University of Gothenburg, Sweden (A.L.J., R.C., R.A., C.R., F.F.H., J.B., F.B.).
Rozita AkramiFrom the Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Sahlgrenska University Hospital, University of Gothenburg, Sweden (A.L.J., R.C., R.A., C.R., F.F.H., J.B., F.B.).
Christoph ReinhardtFrom the Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Sahlgrenska University Hospital, University of Gothenburg, Sweden (A.L.J., R.C., R.A., C.R., F.F.H., J.B., F.B.).
Frida Fåk HålleniusFrom the Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Sahlgrenska University Hospital, University of Gothenburg, Sweden (A.L.J., R.C., R.A., C.R., F.F.H., J.B., F.B.).
Jan BorénFrom the Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Sahlgrenska University Hospital, University of Gothenburg, Sweden (A.L.J., R.C., R.A., C.R., F.F.H., J.B., F.B.).
Fredrik BäckhedFrom the Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Sahlgrenska University Hospital, University of Gothenburg, Sweden (A.L.J., R.C., R.A., C.R., F.F.H., J.B., F.B.).
University of Gothenburg · SESahlgrenska University Hospital · SE

Funding

European Research Council 615362
6 · The paper itself

Abstract

Objective- To investigate the effect of gut microbiota and diet on atherogenesis. Approach and Results- Here, we investigated the interaction between the gut microbiota and diet on atherosclerosis by feeding germ-free or conventionally raised Apoe

Indexed as

Dietary SupplementsDiet, WesternGastrointestinal MicrobiomeMice, Knockout, ApoEAnimal FeedAnimalsAortic DiseasesAtherosclerosisBacteriaCholesterolCholineDisease Models, AnimalIntestinesMaleMethylaminesMice, Inbred C57BLCholesterolCholineMethylaminestrimethyloxamineanimalsatherosclerosischolinegastrointestinal microbiomemice

Identifiers

PMID29903735
PMCPMC6166703
OpenAlexW2808275177

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.