Evidence map›Paper›PMID 29903719›Full record

ArticleAcupuncture in medicine : journal of the British Medical Acupuncture Society2018

Electroacupuncture: a new approach to open the blood-brain barrier in rats recovering from middle cerebral artery occlusion.

Jiangsong Zhang, Xianming Lin, Hui Zhou, Yuanyuan Chen, Shuangkai Xiao, Junyue Jiao, Yibin Zhao, Zhong Di

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acupuncture in medicine : journal of the British Medical Acupuncture Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. The blood-brain barrier: structure, regulation, and drug delivery.Signal transduction and targeted therapy · 2023
    Review
  11. Electroacupuncture of the trigeminal nerve causesFrontiers in cellular neuroscience · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jiangsong Zhang *The Third Clinical Medical College, Zhejiang Chinese Medical University, Department of Neurobiology and Acupuncture Research, Hangzhou, China.ORCID 0000-0001-7760-6850
Xianming Lin *The Third Clinical Medical College, Zhejiang Chinese Medical University, Department of Neurobiology and Acupuncture Research, Hangzhou, China.
Hui ZhouThe Third Clinical Medical College, Zhejiang Chinese Medical University, Department of Neurobiology and Acupuncture Research, Hangzhou, China.
Yuanyuan ChenThe Third Clinical Medical College, Zhejiang Chinese Medical University, Department of Neurobiology and Acupuncture Research, Hangzhou, China.
Shuangkai XiaoThe Third Clinical Medical College, Zhejiang Chinese Medical University, Department of Neurobiology and Acupuncture Research, Hangzhou, China.
Junyue JiaoThe Third Clinical Medical College, Zhejiang Chinese Medical University, Department of Neurobiology and Acupuncture Research, Hangzhou, China.
Yibin ZhaoThe Third Clinical Medical College, Zhejiang Chinese Medical University, Department of Neurobiology and Acupuncture Research, Hangzhou, China.
Zhong DiThe Third Clinical Medical College, Zhejiang Chinese Medical University, Department of Neurobiology and Acupuncture Research, Hangzhou, China.
Zhejiang Chinese Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine for an opening effect on the blood-brain barrier (BBB) in intact rats and rats with experimental ischaemia-reperfusion (I/R) during the recovery period after various electroacupuncture (EA) treatments with different time courses, and to determine whether there is a time-dependent effect. An additional objective was to determine whether this method could induce the penetration of nerve growth factor (NGF) through the BBB.

methodsA middle cerebral artery occlusion (MCAO) model was first established. We chose different stimulation time courses and observed the effects of EA treatment (100 Hz frequency; 2 mA intensity) at GV20 and GV26 on the BBB in rats recovering from MCAO 3 weeks after modelling. The rats were injected with 2% Evans blue (EB) saline. The brain water content was measured using a wet/dry weighing method. The degree of penetration of EB was detected using spectrophotometry and laser confocal microscopy. The rats were then injected with NGF, and the concentration of NGF in the brain tissues was measured using ELISA.

resultsThe increase in the BBB permeability was most notable following the 8 min EA stimulation (P<0.05), which may be advantageous for the targeted delivery of drugs (such as NGF) into the brain. Additionally, this effect did not appear to cause brain oedema (P>0.05) in healthy or MCAO rats.

conclusionsEA treatment for a certain stimulation time at GV20 and GV26 in MCAO rats can increase BBB permeability.

Indexed as

Blood-Brain BarrierElectroacupunctureAnimalsBrainBrain EdemaCapillary PermeabilityDisease Models, AnimalFluorescenceInfarction, Middle Cerebral ArteryMaleNerve Growth FactorRatsRats, Sprague-DawleyNerve Growth Factorelectrical stimulation therapyelectroacupunctureneurologystroke

Identifiers

PMID29903719
PMCPMC6287560
OpenAlexW2808540601

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.