ReviewBrain research2018
The touchy business of gastrointestinal (GI) mechanosensitivity.
Review in Brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Modeling based insights into mechanical dysfunction in esophageal motility disorders.PLoS computational biology · 2025Article
- Regulation of Autonomic Motility in Human Gastric Muscle and the Gastroepiploic Artery by Stretch and pH.Journal of muscle research and cell motility · 2025Article
- Enteroendocrine Cells Sense Sucrose and Alter Enteric Neuron Excitability via Insulin Signaling.Advanced biology · 2025Article
- Identification of vagal afferent nerve endings in the mouse colon and their spatial relationship with enterochromaffin cells.Cell and tissue research · 2024Article
- Development and validation of the Gastrointestinal Symptom Severity Scale in Spanish children and adolescents.European journal of pediatrics · 2024Article
- Psychometric Properties of the Gastrointestinal Symptom Severity Scale in a Sample of Adolescents and Young Adults.Journal of clinical medicine · 2024Article
- Piezo channels in the intestinal tract.Frontiers in physiology · 2024Review
- Intestinal enteroendocrine cells rely on ryanodine and IPThe Journal of physiology · 2023Article
- Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract.International journal of molecular sciences · 2022Review
- Dynamic Observation of Retinal Response to Pressure Elevation in a Microfluidic Chamber.Analytical chemistry · 2022Article
- Gut feelings: mechanosensing in the gastrointestinal tract.Nature reviews. Gastroenterology & hepatology · 2022Review
- Studying Murine Small Bowel Mechanosensing of Luminal Particulates.Journal of visualized experiments : JoVE · 2022Article
- Specialized Mechanosensory Epithelial Cells in Mouse Gut Intrinsic Tactile Sensitivity.Gastroenterology · 2022Article
- Abdominal massage alleviates functional diarrhea in immature rats via modulation of intestinal microbiota and tight junction protein.Frontiers in pediatrics · 2022Article
- The role of mechanosensitive ion channels in the gastrointestinal tract.Frontiers in physiology · 2022Review
- Current applications of mathematical models of the interstitial cells of Cajal in the gastrointestinal tract.WIREs mechanisms of disease · 2021Review
- In Pursuit of the Epithelial Mechanosensitivity Mechanisms.Frontiers in endocrinology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The gastrointestinal (GI) tract's normal function depends on its ability to propel, mix, and store contents in a highly coordinated fashion. An ability to sense mechanical forces is therefore fundamental to normal GI tract operation. There are several mechanosensory circuits distributed throughout the GI tract. These circuits rely on a range of proposed specialized and non-specialized mechanosensory cells that include epithelial enterochromaffin (EC) cells, both intrinsic and extrinsic sensory neurons, glia, interstitial cells of Cajal (ICC), and smooth muscle cells. While the anatomy of these circuits is established, the molecular mechanisms and functions are still poorly understood. In this review, we focus on the neuro-epithelial mechanosensory circuit in the gut, composed of epithelial EC cells and sensory neurons, both intrinsic and extrinsic. Intriguingly, this circuit closely resembles the light touch circuit in the skin that is composed of an epithelial Merkel cell and an afferent sensory neuron, suggesting that the basic building blocks may be retained in diverse mechanosensory systems. We compare the gross and molecular anatomy and physiology of these circuits and dissect the roles of GI neuro-epithelial mechanosensory, or "GI touch", circuitry in GI health and disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.