Evidence map›Paper›PMID 29903616›Full record

ReviewBrain research2018

Mechanisms of vagal plasticity influencing feeding behavior.

Guillaume de Lartigue, Chelsea Xu

Open access · greenAbstract readReview
In one paragraph

Review in Brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Enteroendocrine cells wire the gut-brain vagal axis.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Guillaume de LartigueThe John B. Pierce Laboratory, New Haven, CT, USA. Electronic address: gdelartigue@jbbierce.org.
Chelsea XuDepartment Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.
John B. Pierce Laboratory · USYale University · US

Funding

Evaluating the therapeutic potential of vagal CART circuitry for treating metabolic diseaseR01DK116004 · NIDDK · UNIVERSITY OF FLORIDA · PI Guillaume FH de Lartigue · 2018 to 2026
$3.6M
The role of vagal afferent neurons in regulating feeding behaviorR00DK094871 · NIDDK · JOHN B. PIERCE LABORATORY, INC. · PI DE LARTIGUE, GUILLAUME FH · 2015 to 2017
$718k
NIDDK NIH HHS R00 DK094871NIDDK NIH HHS R01 DK116004
6 · The paper itself

Abstract

Sensory neurons of the vagus nerve receive many different peripheral signals that can change rapidly and frequently throughout the day. The ability of these neurons to convey the vast array of nuanced information to the brain requires neuronal adaptability. In this review we discuss evidence for neural plasticity in vagal afferent neurons as a mechanism for conveying nuanced information to the brain important for the control of feeding behavior. We provide evidence that synaptic plasticity, changes in membrane conductance, and neuropeptide specification are mechanisms that allow flexibility in response to metabolic cues that can be disrupted by chronic intake of energy dense diets.

Indexed as

AnimalsFeeding BehaviorHumansNeuronal PlasticityNeuropeptidesVagus NerveNeuropeptidesConductanceFeedingNeuropeptideObesityPlasticityVagus nerve

Identifiers

PMID29903616
PMCPMC6996925
OpenAlexW2808525787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.