Evidence map›Paper›PMID 29903580›Full record

ReviewTrends in pharmacological sciences2018

An Emerging Circuit Pharmacology of GABA

Elif Engin, Rebecca S Benham, Uwe Rudolph

Abstract readReview
In one paragraph

Review in Trends in pharmacological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Effects of diazepam on hippocampal blood flow in people at clinical high risk for psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Trial
  4. Review
  5. Article
  6. Article
  7. Enantiomer-specific modulation of GABAPsychopharmacology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. The role of GABANeuroscience and biobehavioral reviews · 2026
    Review
  13. Review
  14. Article
  15. Article
  16. GABADrug design, development and therapy · 2026
    Review
  17. Article
  18. Review
  19. Article
  20. Article

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elif EnginLaboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA. Electronic address: eengin@mclean.harvard.edu.
Rebecca S BenhamLaboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA.
Uwe RudolphLaboratory of Genetic Neuropharmacology, McLean Hospital, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA. Electronic address: urudolph@mclean.harvard.edu.

Funding

A GABA Pathway to Faster Acting AntidepressantsR01MH095905 · NIMH · MCLEAN HOSPITAL · PI RUDOLPH, UWE · 2012 to 2016
$2.0M
Genetic Mapping of Neuronal Circuits Involved in Regulation of Anxiety and FearR01MH080006 · NIMH · MCLEAN HOSPITAL · PI RUDOLPH, UWE · 2009 to 2013
$1.9M
Regional actions of general anesthetics in inhibitory hippocampal networksR01GM086448 · NIGMS · MCLEAN HOSPITAL · PI RUDOLPH, UWE · 2009 to 2012
$1.9M
Intrahippocampal dynamics underlying cognitive rigidityK01MH107787 · NIMH · MCLEAN HOSPITAL · PI ENGIN, ELIF · 2016 to 2019
$696k
NIGMS NIH HHS R01 GM086448NIMH NIH HHS K01 MH107787NIMH NIH HHS R01 MH080006NIMH NIH HHS R01 MH095905
6 · The paper itself

Abstract

In the past 20 years we have learned a great deal about GABA

Indexed as

AnimalsBenzodiazepinesBrainGABA-A Receptor AgonistsGABA-A Receptor Antagonistsgamma-Aminobutyric AcidHumansNeuronsReceptors, GABA-ABenzodiazepinesGABA-A Receptor AgonistsGABA-A Receptor Antagonistsgamma-Aminobutyric AcidReceptors, GABA-AaddictionanxietydepressionGABA(A) receptorhippocampusmemory

Identifiers

PMID29903580
PMCPMC6056379

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.