Evidence map›Paper›PMID 29903508›Full record

ArticleSurgery2018

Rapid TEG efficiently guides hemostatic resuscitation in trauma patients.

Julia R Coleman, Ernest E Moore, Michael P Chapman, Anirban Banerjee, Christopher C Silliman, Arsen Ghasabyan, James Chandler, Jason M Samuels, Angela Sauaia

Abstract read
In one paragraph

Article in Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Detection of Acute Traumatic Coagulopathy by Viscoelastic Haemostatic Assays Compared to Standard Laboratory Tests: A Systematic Review.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023
    Review
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  4. Review
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Observational
  11. Trauma Resuscitation Consideration: Sex Matters.Journal of the American College of Surgeons · 2019
    Article
  12. Redefining postinjury fibrinolysis phenotypes using two viscoelastic assays.The journal of trauma and acute care surgery · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Julia R ColemanUniversity of Colorado-Denver, Aurora, CO. Electronic address: julia.coleman@ucdenver.edu.
Ernest E MooreDenver Health Medical Center, Denver, CO. Electronic address: Ernest.moore@dhha.org.
Michael P ChapmanUniversity of Colorado-Denver, Aurora, CO.
Anirban BanerjeeUniversity of Colorado-Denver, Aurora, CO.
Christopher C SillimanUniversity of Colorado-Denver, Aurora, CO.
Arsen GhasabyanDenver Health Medical Center, Denver, CO.
James ChandlerDenver Health Medical Center, Denver, CO.
Jason M SamuelsUniversity of Colorado-Denver, Aurora, CO.
Angela SauaiaUniversity of Colorado-Denver, Aurora, CO.
University of Colorado Denver · USDenver Health Medical Center · US

Funding

Analysis and Characterization of Trauma-Induced CoagulopathyUM1HL120877 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MORRISSEY, JAMES H., WISNIEWSKI, STEPHEN R · 2013 to 2019
$26.6M
Trauma Reprograms CellsP50GM049222 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI BANERJEE, ANIRBAN · 1993 to 2017
$26.1M
Mechanisms of Trauma-Induced CoagulopathyT32GM008315 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Mitchell Cohen, ELIZABETH J. KOVACS · 1991 to 2026
$7.1M
NHLBI NIH HHS UM1 HL120877NIGMS NIH HHS P50 GM049222NIGMS NIH HHS T32 GM008315
6 · The paper itself

Abstract

backgroundSeveral thrombelastography functional assays have been developed to guide transfusion in injured patients, but how this acceleration of thrombelastography affects its ability to predict massive transfusion is unknown. The objective of this study is to compare citrated native, citrated kaolin, and citrated rapid thromboelastographies for their prediction of massive transfusion after trauma. We hypothesized that citrated native thrombelastography best predicts massive transfusion.

methodsData were collected as part of a prospective study of trauma activation patients. All patients received citrated native, citrated kaolin, or citrated rapid thromboelastographies. Logistic regression was used to assess the predictive performance of different thrombelastography assays for massive transfusion.

resultsMeasurements for all three TEG activating systems was available for 343 patients; 57 (16.6%) required a massive transfusion. Compared to citrated rapid thromboelastographies, citrated kaolin thromboelastographies performed better for activated clotting time/rapid and citrated native thromboelastographies for maximum amplitude and angle. Yet, the 95% confidence intervals overlapped considerably, suggesting the citrated rapid thromboelastographies produced comparable results to the other assays for activated clotting time/reaction time, maximum amplitude, and angle.

conclusionThere was substantial overlap in the performance of the different thrombelastography assays, suggesting citrated rapid thrombelastography is a quick and effective method to guide hemostatic resuscitation in trauma patients and does not perform inferiorly to the citrated native or citrated kaolin thrombelastography despite the addition of activation factors.

Indexed as

Blood TransfusionHemostatic TechniquesThrombelastographyAdultAnticoagulantsCitric AcidFemaleHemorrhageHumansKaolinLogistic ModelsMaleMiddle AgedNeeds AssessmentPredictive Value of TestsProspective StudiesAnticoagulantsCitric AcidKaolin

Identifiers

PMID29903508
PMCPMC6108915
OpenAlexW2808556985

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.