ArticleThe Lancet. Global health2018
Body-mass index, blood pressure, and cause-specific mortality in India: a prospective cohort study of 500 810 adults.
Article in The Lancet. Global health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Pooled it
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- Blood pressure, hypertension and the risk of abdominal aortic aneurysms: a systematic review and meta-analysis of cohort studies.European journal of epidemiology · 2019Pooled it
- The effect of exercise training level on arterial stiffness after clinically significant weight loss.Clinical obesity · 2023Trial
- Combined impact of smoking, alcohol and social inequalities on premature mortality in urban India.Nature health · 2026Article
- Explainable machine learning for predicting coronary heart disease risk in patients with carotid atherosclerosis: A retrospective study with SHAP and decision curve analysis.Journal of clinical and translational science · 2026Article
- Income-based inequalities in risk factors of NCDs and inequities of preventive care services amongst 202,682 adults: a cross-sectional study of South Asia Biobank.BMC medicine · 2025Article
- Conventional and genetic associations of BMI with major vascular and non-vascular disease incidence and mortality in a relatively lean Chinese population: U-shaped relationship revisited.International journal of epidemiology · 2024Article
- Cohort Profile: Indian Study of Healthy Ageing (ISHA-Barshi).International journal of epidemiology · 2024Article
- Exploring lipodystrophy gene expression in adipocytes: unveiling insights into the pathogenesis of insulin resistance, type 2 diabetes, and clustering diseases (metabolic syndrome) in Asian Indians.Frontiers in endocrinology · 2024Article
- Body composition and risk factors for cardiovascular disease in global multi-ethnic populations.International journal of obesity (2005) · 2023Article
- Article
- Gender-associated cardiometabolic risk profiles and health behaviors in patients with type 2 diabetes: a cross-sectional analysis of the Joint Asia Diabetes Evaluation (JADE) program.The Lancet regional health. Western Pacific · 2023Article
- Body Composition and Risk of Vascular-Metabolic Mortality Risk in 113 000 Mexican Men and Women Without Prior Chronic Disease.Journal of the American Heart Association · 2023Article
- Increased 10-year cardiovascular disease risk in depressed patients with coexisting subclinical hypothyroidism.Frontiers in psychiatry · 2023Article
- Mortality Associated with AmbientEnvironmental health perspectives · 2022Article
- Food environments and obesity: A geospatial analysis of the South Asia Biobank, income and sex inequalities.SSM - population health · 2022Article
- Combined Lifestyle Factors and Risk of All-Cause and Cause-Specific Mortality Among Participants in the Linxian Nutrition Intervention Trial: A Cohort, Observational Study.Frontiers in cardiovascular medicine · 2022Article
- Association Between Body Mass Index and All-Cause Mortality in a Prospective Cohort of Southern Chinese Adults Without Morbid Obesity.Frontiers in physiology · 2022Article
- Body-mass index, blood pressure, diabetes and cardiovascular mortality in Cuba: prospective study of 146,556 participants.BMC public health · 2021Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe association between cause-specific mortality and body-mass index (BMI) has been studied mainly in high-income countries. We investigated the relations between BMI, systolic blood pressure, and mortality in India.
methodsMen and women aged 35 years or older were recruited into a prospective study from the general population in Chennai, India between Jan 1, 1998, and Dec 31, 2001. Participants were interviewed (data collected included age, sex, education, socioeconomic status, medical history, tobacco smoking, and alcohol intake) and measured (height, weight, and blood pressure). Deaths were identified by linkage to Chennai city mortality records and through active surveillance by household visits from trained graduate non-medical fieldworkers. After the baseline survey, households were visited once in 2002-05, then biennially until 2015. During these repeat visits, structured narratives of any deaths that took place before March 31, 2015, were recorded for physician coding. During 2013-14, a random sample of participants was also resurveyed as per baseline to assess long-term variability in systolic blood pressure and BMI. Cox regression (standardised for tobacco, alcohol, and social factors) was used to relate mortality rate ratios (RRs) at ages 35-69 years to systolic blood pressure, BMI, or BMI adjusted for usual systolic blood pressure.
findings500 810 participants were recruited. After exclusion of those with chronic disease or incomplete data, 414 746 participants aged 35-69 years (mean 46 [SD 9]; 45% women) remained. At recruitment, mean systolic blood pressure was 127 mm Hg (SD 15), and mean BMI was 23·2 kg/m
interpretationIn this South Asian population, BMI was little associated with vascular mortality, even though increased BMI is associated with increased systolic blood pressure, which in turn is associated with increased vascular mortality. Hence, some close correlates of below-average BMI must have important adverse effects, which could be of relevance in all populations.
fundingUK Medical Research Council, British Heart Foundation, Cancer Research UK.
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