ArticleBiological research for nursing2018
Dose of Early Therapeutic Mobility: Does Frequency or Intensity Matter?
Article in Biological research for nursing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Korean clinical practice guidelines for rehabilitation in critically ill patients and post-intensive care syndrome.Acute and critical care · 2026Guideline
- Preventive effects of early mobilisation on delirium incidence in critically ill patients: systematic review and meta-analysis.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Pooled it
- A Systematic Review and Meta-Analysis of the Role of Peripheral Inflammation in Delirium.Brain and behavior · 2025Pooled it
- Nurse-involved early mobilization in the intensive care unit: A systematic review and meta-analysis.Nursing in critical care · 2025Pooled it
- Reporting of nutritional screening, status, and intake in trials of nutritional and physical rehabilitation following critical illness: a systematic review.The American journal of clinical nutrition · 2025Pooled it
- Korean Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients and Post-Intensive Care Syndrome.Annals of rehabilitation medicine · 2026Article
- Dose reporting and dose-stratified effects of early mobilization in mechanically ventilated adult ICU patients: a systematic review and meta-analysis.Frontiers in medicine · 2026Review
- Myokine Secretion Dynamics and Their Role in Critically Ill Patients: A Scoping Review.Journal of clinical medicine · 2025Review
- Japanese Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients 2023 (J-ReCIP 2023).Journal of intensive care · 2023Review
- Current Practice and Barriers to the Implementation of Mobilization in ICUs in Japan: A Multicenter Prospective Cohort Study.Journal of clinical medicine · 2023Article
- Investigating the impact of physical activity interventions on delirium outcomes in intensive care unit patients: A systematic review and meta-analysis.Journal of the Intensive Care Society · 2023Review
- Clustering of critically ill patients using an individualized learning approach enables dose optimization of mobilization in the ICU.Critical care (London, England) · 2023Observational
- Respiratory Support Adjustments and Monitoring of Mechanically Ventilated Patients Performing Early Mobilization: A Scoping Review.Critical care explorations · 2021Article
- A novel early mobility bundle improves length of stay and rates of readmission among hospitalized general medicine patients.Journal of community hospital internal medicine perspectives · 2020Article
- Early Therapeutic Mobility and Changes in Scores for Pain and Fatigue.Critical care nurse · 2019Article
- Article
- Early mobilisation in mechanically ventilated patients: a systematic integrative review of definitions and activities.Journal of intensive care · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveInvestigate the feasibility of a nurse-led mobility protocol and compare the effects of once- versus twice-daily episodes of early therapeutic mobility (ETM) and low- versus moderate-intensity ETM on serum biomarkers of inflammation and selected outcomes in critically ill adults.
designRandomized interventional study with repeated measures and blinded assessment of outcomes.
settingFour adult intensive care units (ICUs) in two academic medical centers. SUBJECTS: Fifty-four patients with > 48 hr of mechanical ventilation (MV).
interventionPatients were assigned to once- or twice-daily ETM via sealed envelope randomization at enrollment. Intensity of (in-bed vs. out-of-bed) ETM was administered according to protocolized patient assessment. MEASUREMENTS: Interleukins 6, 10, 8, 15, and tumor necrosis factor-α were collected from serum before and after ETM; change scores were used in the analyses. Manual muscle and handgrip strength, delirium onset, duration of MV, and ICU length of stay (LOS) were evaluated as patient outcomes. MAIN
resultsHypotheses regarding the inflammatory biomarkers were not supported based on confidence intervals. Twice-daily intervention was associated with reduced ICU LOS. Moderate-intensity (out-of-bed) ETM was associated with greater manual muscle test scores and handgrip strength and reduced occurrence of delirium.
conclusionFindings from this study suggest that nurses can provide twice-daily mobility interventions that include sitting on the edge of the bed once patients have a stable status without altering a pro-inflammatory serum biomarker profile.
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Registered trials
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