Evidence map›Paper›PMID 29902838›Full record

ArticleMolecules and cells2018

Icariside II Promotes the Differentiation of Adipose Tissue-Derived Stem Cells to Schwann Cells to Preserve Erectile Function after Cavernous Nerve Injury.

Tao Zheng, Tian-Biao Zhang, Chao-Liang Wang, Wei-Xing Zhang, Dong-Hui Jia, Fan Yang, Yang-Yang Sun, Xiao-Ju Ding, Rui Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules and cells, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
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  5. Review
  6. Review
  7. Adipose-derived stem cells modified byNeural regeneration research · 2020
    Article
  8. Article
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tao ZhengDepartment of Andrology, Institute of Andrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Tian-Biao ZhangDepartment of Andrology, Institute of Andrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Chao-Liang WangDepartment of Andrology, Institute of Andrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Wei-Xing ZhangDepartment of Andrology, Institute of Andrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Dong-Hui JiaDepartment of Andrology, Institute of Andrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Fan YangDepartment of Andrology, Institute of Andrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yang-Yang SunDepartment of Andrology, Institute of Andrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Xiao-Ju DingDepartment of Andrology, Institute of Andrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Rui WangDepartment of Andrology, Institute of Andrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Icariside II (ICA II) is used in erectile dysfunction treatment. Adipose tissue-derived stem cells (ADSCs) are efficient at improving erectile function. This study aimed to explore the action mechanism of ADSCs in improving erectile function. ADSCs were isolated from the adipose tissues of rats. Cell proliferation was determined using the Cell Counting Kit-8 (CCK-8) assay. The expressions of mRNA and protein were determined separately through qRT-PCR and western blot. The endogenous expressions of related genes were regulated using recombinant plasmids and cell transfection. A Dual-Luciferase Reporter Assay was performed to determine the interaction between miR-34a and STAT3. Rat models with bilateral cavernous nerve injuries (BCNIs) were used to assess erectile function through the detection of mean arterial pressure (MAP) and intracavernosal pressure (ICP). ICA II promoted ADSCs' proliferation and differentiation to Schwann cells (SCs) through the inhibition of miR-34a. Suppressed miR-34a promoted the differentiation of ADSCs to SCs by upregulating STAT3. ICA II promoted the differentiation of ADSCs to SCs through the miR-34a/STAT3 pathway. The combination of ICA II and ADSCs preserved the erectile function of the BCNI model rats. ADSCs treated with ICA II markedly preserved the erectile function of the BCNI model rats, which was reversed through miR-34a overexpression. ICA II promotes the differentiation of ADSCs to SCs through the miR-34a/STAT3 pathway, contributing to erectile function preservation after the occurrence of a cavernous nerve injury.

Indexed as

Adipose TissueAdultCell DifferentiationDrugs, Chinese HerbalErectile DysfunctionFlavonoidsHemangioma, Cavernous, Central Nervous SystemHumansMaleSchwann CellsTransfectionbaohuoside IDrugs, Chinese HerbalFlavonoidsADSCserectile functionICA IImiR-34aSTAT3

Identifiers

PMID29902838
PMCPMC6030246
OpenAlexW2904366884

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.