Evidence map›Paper›PMID 29902550›Full record

ReviewBiochimica et biophysica acta. Molecular basis of disease2018

FGF binding proteins (FGFBPs): Modulators of FGF signaling in the developing, adult, and stressed nervous system.

Thomas Taetzsch, Vanessa L Brayman, Gregorio Valdez

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta. Molecular basis of disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Klf5a in Endoderm Promotes Pharyngeal Cartilage Morphogenesis.International journal of molecular sciences · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Decoding the Function ofAnimals : an open access journal from MDPI · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thomas TaetzschVirginia Tech Carilion Research Institute, Roanoke, VA, USA. Electronic address: taetzscht@vtc.vt.edu.
Vanessa L BraymanVirginia Tech Carilion Research Institute, Roanoke, VA, USA; Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA, USA. Electronic address: vbrayman@vt.edu.
Gregorio ValdezVirginia Tech Carilion Research Institute, Roanoke, VA, USA; Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA. Electronic address: gvaldez1@vtc.vt.edu.

Funding

Targeting the fibroblast growth factor binding protein-1 to slow degeneration of neuromuscular junctionsR01AG055545 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2017 to 2021
$2.2M
Role of Target-derived FGFs in Maintaining and Repairing SynapsesK01NS085071 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2013 to 2015
$679k
Synaptic FGFs are required and sufficient to maintain and repair aged NMJsR56AG051501 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2015 to 2015
$377k
NIA NIH HHS R01 AG055545NIA NIH HHS R56 AG051501NIH HHS K01NS085071NIH HHS R56AG051501NIH HHS RO1AG055545NINDS NIH HHS K01 NS085071
6 · The paper itself

Abstract

Members of the fibroblast growth factor (FGF) family are involved in a variety of cellular processes. In the nervous system, they affect the differentiation and migration of neurons, the formation and maturation of synapses, and the repair of neuronal circuits following insults. Because of the varied yet critical functions of FGF ligands, their availability and activity must be tightly regulated for the nervous system, as well as other tissues, to properly develop and function in adulthood. In this regard, FGF binding proteins (FGFBPs) have emerged as strong candidates for modulating the actions of secreted FGFs in neural and non-neural tissues. Here, we will review the roles of FGFBPs in the peripheral and central nervous systems.

Indexed as

Nervous System Physiological PhenomenaAnimalsCarrier ProteinsCell DifferentiationCell MovementCentral Nervous SystemFibroblast Growth FactorsHumansNeuronsPeripheral Nervous SystemSignal TransductionStress, PhysiologicalSynapsesCarrier ProteinsFibroblast Growth FactorsAgingDiseasesFGFBPInjuryNeuromuscular junctionSynapse

Identifiers

PMID29902550
PMCPMC6417432

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.