Evidence map›Paper›PMID 29902467›Full record

ArticleBrain research2018

Correcting deregulated Fxyd1 expression rescues deficits in neuronal arborization and potassium homeostasis in MeCP2 deficient male mice.

Valerie Matagne, Joyce Wondolowski, Matthew Frerking, Mohammad Shahidullah, Nicholas A Delamere, Ursula S Sandau, Sarojini Budden, Sergio R Ojeda

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Valerie MatagneDivision of Neuroscience, Oregon National Primate Research Center/Oregon Health & Science University, Beaverton, OR 97006, USA. Electronic address: Valerie.matagne@univ-amu.fr.
Joyce WondolowskiNeuroscience Graduate Program, Oregon Health and Sciences University, Portland, OR 97239, USA. Electronic address: jwondolowski@gmail.com.
Matthew FrerkingDepartments of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: frerking@ohsu.edu.
Mohammad ShahidullahDepartment of Physiology, University of Arizona, Tucson, AZ 85721, USA. Electronic address: shahidua@email.arizona.edu.
Nicholas A DelamereDepartment of Physiology, University of Arizona, Tucson, AZ 85721, USA. Electronic address: delamere@email.arizona.edu.
Ursula S SandauDivision of Neuroscience, Oregon National Primate Research Center/Oregon Health & Science University, Beaverton, OR 97006, USA. Electronic address: sandauu@ohsu.edu.
Sarojini BuddenDivision of Developmental Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: sbudden@comcast.net.
Sergio R OjedaDivision of Neuroscience, Oregon National Primate Research Center/Oregon Health & Science University, Beaverton, OR 97006, USA. Electronic address: ojedas@ohsu.edu.
Oregon Health & Science University · USOregon National Primate Research Center · USUniversity of Arizona · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
TRPV4 as a remote controller of lens functionR01EY009532 · NEI · UNIVERSITY OF LOUISVILLE · PI DELAMERE, NICHOLAS A · 1993 to 2024
$8.0M
SOLUTE TRANSPORT MECHANISMS IN THE CILIARY BODYR01EY006915 · NEI · UNIVERSITY OF LOUISVILLE · PI DELAMERE, NICHOLAS A · 1986 to 2013
$2.8M
Hemichannels, TRPV4 and a mechanosensitive form of autocrine regulation in the NPER01EY029171 · NEI · UNIVERSITY OF ARIZONA · PI DELAMERE, NICHOLAS A · 2019 to 2023
$2.2M
The Role of mGluR8 in AnxietyR01MH077647 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI RABER, JACOB · 2007 to 2011
$1.9M
Excitatory synaptic transmission onto hippocampal interneuronsR01NS064317 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI FRERKING, MATTHEW E · 2010 to 2013
$1.2M
EVALUATION OF TULP1 IN THE RETINAF32EY006915 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI HAGSTROM, STEPHANIE A · 1998 to 2000
$32k
NEI NIH HHS F32 EY006915NEI NIH HHS R01 EY006915NEI NIH HHS R01 EY009532NEI NIH HHS R01 EY029171NIH HHS P51 OD011092NIMH NIH HHS R01 MH077647NINDS NIH HHS R01 NS064317
6 · The paper itself

Abstract

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the MECP2 gene. In the absence of MeCP2, expression of FXYD domain-containing transport regulator 1 (FXYD1) is deregulated in the frontal cortex (FC) of mice and humans. Because Fxyd1 is a membrane protein that controls cell excitability by modulating Na

Indexed as

AnimalsCell MembraneDisease Models, AnimalGene Expression RegulationHomeostasisMaleMembrane ProteinsMethyl-CpG-Binding Protein 2MiceMice, Inbred C57BLMice, KnockoutNeuronal PlasticityNeuronsPhenotypePhosphoproteinsPotassiumMecp2 protein, mouseMembrane ProteinsMethyl-CpG-Binding Protein 2phospholemmanPhosphoproteinsPotassiumSodium-Potassium-Exchanging ATPaseMecp2 deficiencyNeuronal morphologyPotassium effluxRett syndromeSodium-potassium ATPase

Identifiers

PMID29902467
PMCPMC7864099
OpenAlexW2808664339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.