ArticleCell host & microbe2018
Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion.
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In one paragraph
Article in Cell host & microbe, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 258 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
258citing papers in PubMed, 3 pooled it
12.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
258 citing papers in PubMed, 3 syntheses or guidelines pooled it, 417 citations in OpenAlex.
- Microbial dysbiosis in systemic lupus erythematosus: a scientometric study.Frontiers in microbiology · 2024Pooled it
- Gut microbiota bridges dietary nutrients and host immunity.Science China. Life sciences · 2023Pooled it
- Pooled it
- Indole-3-acetic acid production is rare among gut bacteria and reflects OFOR-driven amino acid oxidation in acetogens.Gut microbes · 2026Article
- Irritable bowel syndrome.Nature reviews. Disease primers · 2026Review
- Microbial-derived tryptophan metabolites in the infant gut associate with increased risk of asthma following cesarean section.Nature communications · 2026Article
- Enterochromaffin cells as a cellular integration hub for cooperative microbial signaling to modulate gut serotonin and motility.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Tryptophan Metabolism in Digestive and Extra-Digestive Diseases: Mechanisms, Clinical Implications, and Therapeutic Perspectives.Nutrients · 2026Review
- Gut Microbiota Alter Colonic Expression of Genes Encoding Drug Transporters and Drug-Metabolizing Enzymes in Mice.International journal of molecular sciences · 2026Article
- Mechanisms and Implications of Gut Microbiota-Derived Metabolites in the Regulation of Poultry Defensins.Animals : an open access journal from MDPI · 2026Review
- Tracing NADCell reports · 2026Article
- IL-1β pathway-dependent regulation of glutamate receptor activity by gut microbiota in bipolar depression.Journal of Zhejiang University. Science. B · 2026Article
- Plant-Derived Foods and Medicines as Modulators of the Gut Microbiome: Molecular Interactions and Implications for Disease and Therapy.Molecules (Basel, Switzerland) · 2026Review
- Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut.Nature reviews. Gastroenterology & hepatology · 2026Review
- Gut Microbiota-Mediated Modulation of Intestinal Serotonin by Tea Polyphenols: Potential Mechanisms and Implications for Metabolic Health.Nutrients · 2026Review
- Gut microbiota and their role in male reproductive health.NPJ science of food · 2026Review
- Cell Signaling by Tryptophan Catabolism.Biochemistry · 2026Review
- The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health.Nature reviews. Gastroenterology & hepatology · 2026Article
- Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids.Nature microbiology · 2026Article
- Towards microbiome-informed strategies for predicting and preventing pregnancy complications.Reproduction & fertility · 2026Review
198 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 1 country.
Yogesh BhattaraiDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
Brianna B WilliamsDepartment of Bioengineering and ChEM-H, Stanford University, Stanford, CA 94305, USA.
Eric J BattaglioliDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
Weston R WhitakerDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94304, USA.
Lisa TillDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Madhusudan GroverDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
David R LindenDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Yasutada AkibaDepartment of Medicine, School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA 90073, USA; Brentwood Biomedical Research Institute, Los Angeles, CA 90073, USA.
Karunya K KandimallaDepartment of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USA.
Nicholas C ZachosDepartment of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Jonathan D KaunitzDepartment of Medicine, School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA 90073, USA; Brentwood Biomedical Research Institute, Los Angeles, CA 90073, USA; Department of Surgery, School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Justin L SonnenburgDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94304, USA.
Michael A FischbachDepartment of Bioengineering and ChEM-H, Stanford University, Stanford, CA 94305, USA.
Gianrico FarrugiaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA; Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL 32224, USA.
Purna C KashyapDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: kashyap.purna@mayo.edu.
Stanford University · USMayo Clinic · USMayo Clinic in Arizona · USMayo Clinic in Florida · USUniversity of California, Los Angeles · USJohns Hopkins University · USUniversity of Minnesota · USWinnMed · US
Funding
PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI Nicholas F. LaRusso · 2009 to 2026
$22.2MPilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TACHE, YVETTE FRANCE · 1990 to 2019
$18.0MTranslational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0MMechanisms of alteration of GI physiology by gut microbesR01DK114007 · NIDDK · MAYO CLINIC ROCHESTER · PI Purna C Kashyap · 2017 to 2026
$4.7M"Barrier function alterations in post-infectious irritable bowel syndrome"K23DK103911 · NIDDK · MAYO CLINIC ROCHESTER · PI GROVER, MADHUSUDAN · 2015 to 2019
$804kMECHANISMS OF ALTERATION OF GASTROINTESTINAL MOTILITY BY GUT MICROBIOTAK08DK100638 · NIDDK · MAYO CLINIC ROCHESTER · PI KASHYAP, PURNA C · 2014 to 2017
$610kMechanisms of alteration of gastrointestinal physiology by gut microbesR03DK111850 · NIDDK · MAYO CLINIC ROCHESTER · PI KASHYAP, PURNA C · 2017 to 2018
$159kNIDDK NIH HHS K08 DK100638NIDDK NIH HHS K23 DK103911NIDDK NIH HHS P30 DK041301NIDDK NIH HHS P30 DK084567NIDDK NIH HHS P30 DK089502NIDDK NIH HHS R01 DK114007NIDDK NIH HHS R03 DK111850
Abstract
Tryptamine, a tryptophan-derived monoamine similar to 5-hydroxytryptamine (5-HT), is produced by gut bacteria and is abundant in human and rodent feces. However, the physiologic effect of tryptamine in the gastrointestinal (GI) tract remains unknown. Here, we show that the biological effects of tryptamine are mediated through the 5-HT
Indexed as
Intestinal SecretionsAnimalsBacteroides thetaiotaomicronColonEpitheliumFecesGastrointestinal MicrobiomeHumansMiceMice, 129 StrainMice, KnockoutPrimary Cell CultureReceptors, Serotonin, 5-HT4Sex FactorsSpecific Pathogen-Free OrganismsTryptaminesReceptors, Serotonin, 5-HT4tryptamineTryptaminesBacteroides thetaiotaomicronconstipationgenetically engineeredGI transitIBSmicrobiomemotilityphage promotersecretiontryptophan
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.