Evidence map›Paper›PMID 29902391›Full record

ReviewExpert review of neurotherapeutics2018

Sleep disorders and the risk of stroke.

Mollie McDermott, Devin L Brown, Ronald D Chervin

Abstract readReview
In one paragraph

Review in Expert review of neurotherapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 5 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 5 syntheses or guidelines pooled it, 115 citations in OpenAlex.

  1. Pooled it
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  12. Review
  13. Prestroke sleep and stroke: a narrative review.Sleep & breathing = Schlaf & Atmung · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mollie McDermotta Michigan Medicine Stroke Program , Cardiovascular Center , Ann Arbor , MI , USA.
Devin L Browna Michigan Medicine Stroke Program , Cardiovascular Center , Ann Arbor , MI , USA.ORCID 0000-0002-9815-3421
Ronald D Chervina Michigan Medicine Stroke Program , Cardiovascular Center , Ann Arbor , MI , USA.
Michigan Medicine · US

Funding

Multi-Institutional Training in Genetic/Genomic Approaches to Sleep DisordersT32HL110952 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHERVIN, RONALD D, MIGNOT, EMMANUEL J · 2013 to 2022
$5.0M
Reach Out: Randomized Clinical Trial of Emergency Department-Initiated Hypertension Behavioral Intervention Connecting Multiple Health SystemsR01MD011516 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MEURER, WILLIAM JOSEPH, SKOLARUS, LESLI ELIZABETH · 2017 to 2020
$3.3M
Sleep-Disordered Breathing and CPAP after Adenotonsillectomy in ChildrenR01HL105999 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHERVIN, RONALD D · 2012 to 2016
$3.2M
Sleep apnea after stroke: Implications for screening and treatmentR01HL126700 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROWN, DEVIN L, LISABETH, LYNDA D · 2016 to 2019
$3.0M
University of Michigan Regional Coordinating Stroke CenterU10NS086526 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROWN, DEVIN L, SCOTT, PHILLIP · 2013 to 2017
$1.7M
Nocturnal Rostral Fluid Shifts In Stroke Patients With Sleep ApneaR01HL123379 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROWN, DEVIN L, LISABETH, LYNDA D · 2015 to 2018
$1.5M
NHLBI NIH HHS R01 HL105999NHLBI NIH HHS R01 HL123379NHLBI NIH HHS R01 HL126700NHLBI NIH HHS T32 HL110952NIMHD NIH HHS R01 MD011516NINDS NIH HHS U10 NS086526
6 · The paper itself

Abstract

introductionStroke is a major cause of disability and death in the United States and across the world, and the incidence and prevalence of stroke are expected to rise significantly due to an aging population. Obstructive sleep apnea, an established independent risk factor for stroke, is a highly prevalent disease that is estimated to double the risk of stroke. It remains uncertain whether non-apnea sleep disorders increase the risk of stroke. Areas covered: This paper reviews the literature describing the association between incident stroke and sleep apnea, rapid eye movement sleep behavior disorder, restless legs syndrome, periodic limb movements of sleep, insomnia, and shift work. Expert commentary: Trials of continuous positive airway pressure for stroke prevention in sleep apnea patients have been largely disappointing, but additional trials that target populations not yet optimally studied are needed. Self-reported short and long sleep duration may be associated with incident stroke. However, abnormal sleep duration may be a marker of chronic disease, which may itself be associated with incident stroke. The relationship between non-apnea sleep disorders and incident stroke deserves further attention. Identification of specific non-apnea sleep disorders or sleep problems that convey an increased risk for stroke may provide novel targets for stroke prevention.

Indexed as

ExtremitiesEye MovementsHumansMovementPrevalenceRestless Legs SyndromeRisk FactorsSelf ReportShift Work ScheduleSleepSleep Apnea SyndromesSleep Wake DisordersStrokeTime FactorsREM sleep behavior disorderrestless legs syndromesleep apneaSleep-disordered breathingsleep durationstroke

Identifiers

PMID29902391
PMCPMC6300163
OpenAlexW2808527008

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.