ArticlePloS one2018
Finite element analysis of annuloplasty and papillary muscle relocation on a patient-specific mitral regurgitation model.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Effect of Parametric Variation of Chordae Tendineae Structure on Simulated Atrioventricular Valve Closure.Annals of biomedical engineering · 2026Article
- Simulation of Transcatheter Therapies for Atrioventricular Valve Regurgitation in an Open-Source Finite Element Simulation Framework.Annals of biomedical engineering · 2026Article
- A noninvasive method for determining elastic parameters of valve tissue using physics-informed neural networks.Acta biomaterialia · 2025Article
- Article
- A Systematic Review of Individualized Heart Surgery with a Personalized Prosthesis.Journal of personalized medicine · 2023Review
- Computational Modeling of the Subject-Specific Effects of Annuloplasty Ring Sizing on the Mitral Valve to Repair Functional Mitral Regurgitation.Annals of biomedical engineering · 2023Article
- The effects of leaflet material properties on the simulated function of regurgitant mitral valves.Journal of the mechanical behavior of biomedical materials · 2023Article
- A Doppler-exclusive non-invasive computational diagnostic framework for personalized transcatheter aortic valve replacement.Scientific reports · 2023Article
- The Effects of leaflet material properties on the simulated function of regurgitant mitral valves.ArXiv · 2023Article
- In silico analysis provides insights for patient-specific annuloplasty in Barlow's disease.JTCVS open · 2023Article
- Texas TriValve 1.0 : a reverse‑engineered, open model of the human tricuspid valve.Engineering with computers · 2022Article
- A Computational Framework for Atrioventricular Valve Modeling Using Open-Source Software.Journal of biomechanical engineering · 2022Article
- DynaRing: A Patient-Specific Mitral Annuloplasty Ring With Selective Stiffness Segments.Journal of medical devices · 2022Article
- Patient-Specific Three-Dimensional Ultrasound Derived Computational Modeling of the Mitral Valve.Annals of biomedical engineering · 2022Article
- Long-term outcomes of etiology specific annuloplasty ring repair of ischemic mitral regurgitation.Annals of cardiothoracic surgery · 2021Article
- Computer simulations of transapical mitral valve repair with neochordae implantation: Clinical implications.JTCVS open · 2020Article
- A Comprehensive Engineering Analysis of Left Heart Dynamics After MitraClip in a Functional Mitral Regurgitation Patient.Frontiers in physiology · 2020Article
- Isolated and combined effects of papillary muscle approximation and mitral annuloplasty in dilated left ventricles.JRSM cardiovascular diseaseArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesFunctional mitral regurgitation (FMR) is a significant complication of left ventricle (LV) dysfunction associated with poor prognosis and commonly treated by undersized ring annuloplasty. This study aimed to quantitatively simulate the treatment outcomes and mitral valve (MV) biomechanics following ring annulopalsty and papillary muscle relocation (PMR) procedures for a FMR patient.
methodsWe utilized a validated finite element model of the left heart for a patient with severe FMR and LV dilation from our previous study and simulated virtual ring annuloplasty procedures with various sizes of Edwards Classic and GeoForm annuloplasty rings. The model included detailed geometries of the left ventricle, mitral valve, and chordae tendineae, and incorporated age- and gender- matched nonlinear, anisotropic hyperelastic tissue material properties, and simulated chordal tethering at diastole due to LV dilation.
resultsRing annuloplasty with either the Classic or GeoForm ring improved leaflet coaptation and increased the total leaflet closing force while increased posterior mitral leaflet (PML) stresses and strains. Classic rings resulted in larger coaptation forces and areas compared to GeoForm rings. The PMR procedure further improved the leaflet coaptation, decreased the PML stress and strain for both ring shapes and all sizes in this patient model.
conclusionsThis study demonstrated that a rigorously developed patient-specific computational model can provide useful insights into annuloplasty repair techniques for the treatment of FMR patients and could potentially serve as a tool to assist in pre-operative planning for MV repair surgical or interventional procedures.
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