ArticlePloS one2018
Sex differences in default mode and dorsal attention network engagement.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Possible influence of sex on the relationship between dual-task gait costs and cognitive decline in older adults.PloS one · 2025Article
- Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.Nature. Mental health · 2025Article
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- Altered temporal-parietal morphological similarity networks in non-small cell lung cancer patients following chemotherapy: an MRI preliminary study.Brain imaging and behavior · 2022Article
- Sex differences in the functional topography of association networks in youth.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Sex Moderates Reward- and Loss-Related Neural Correlates of Triarchic-Model Traits and Antisocial Behavior.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
- Sex differences in the behavioral inhibition system and ventromedial prefrontal cortex connectivity.Social cognitive and affective neuroscience · 2022Article
- Sex differences in brain regional homogeneity during acute abstinence in cocaine use disorder.Addiction biology · 2022Article
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- In search of sex-related mediators of affective illness.Biology of sex differences · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Focusing on sex differences is necessary to fully understand basic neurobiological processes such as the engagement of large-scale brain networks involved in attention. Prior work suggests that women show enhanced attention during tasks of reward/punishment relative to men. Yet, sex differences in the engagement of neural networks sub serving internal and external focus has been unexplored in regard to reward and punishment. Using data from a large sample (n = 190) of healthy participants from the Human Connectome Project, we investigated sex differences in default mode network (DMN), dorsal attention network (DAN), and frontal parietal network (FPN) activation during exposure to reward and punishment. To determine if sex differences are specific to valenced stimuli, we analyzed network activation during working memory. Results indicate that, relative to men, women have increased suppression of the DMN and greater activation of the DAN during exposure to reward and punishment. Given the relative roles of these networks in internal (DMN) and external (DAN) attention, this pattern of activation suggests that women have enhanced external attention to reward and punishment. In contrast, there were no sex differences in network activation during working memory, indicating that this sex difference is specific to the processing of reward and punishment. These findings suggest a neurobiological explanation for prior work showing women have greater sensitivity to reward/punishment and are more prone to psychiatric disorders characterized by enhanced attention to such stimuli. Furthermore, given the large sample from the Human Connectome Project, the current findings provide general implications for the study of sex as a biological variable in investigation of reward processes.
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