ArticlePloS one2018
The effect of pulsed electromagnetic field exposure on osteoinduction of human mesenchymal stem cells cultured on nano-TiO2 surfaces.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Insights into bone and cartilage responses to pulsed electromagnetic field stimulation: a review with quantitative comparisons.Frontiers in bioengineering and biotechnology · 2025Review
- The Future of Bone Repair: Emerging Technologies and Biomaterials in Bone Regeneration.International journal of molecular sciences · 2024Review
- Role of Pulsed Electromagnetic Field on Alveolar Bone Remodeling during Orthodontic Retention Phase in Rat Models.Dentistry journal · 2024Article
- Energizing Healing with Electromagnetic Field Therapy in Musculoskeletal Disorders.Journal of orthopaedics and sports medicine · 2024Article
- Application of magnetism in tissue regeneration: recent progress and future prospects.Regenerative biomaterials · 2024Review
- Human Ovarian Follicular Fluid Mesenchymal Stem Cells Express Osteogenic Markers When Cultured on Bioglass 58S-Coated Titanium Scaffolds.Materials (Basel, Switzerland) · 2023Article
- Harnessing electromagnetic fields to assist bone tissue engineering.Stem cell research & therapy · 2023Review
- Biophysical therapy using the pulsating electromagnetic field as adjunctive therapy for implant osseointegration - A review.National journal of maxillofacial surgery · 2022Review
- Biomaterials to enhance stem cell transplantation.Cell stem cell · 2022Review
- Electromagnetic field exposure as a plausible approach to enhance the proliferation and differentiation of mesenchymal stem cells in clinically relevant scenarios.Journal of Zhejiang University. Science. B · 2022Review
- Regulatory effects of miR-28 on osteogenic differentiation of human bone marrow mesenchymal stem cells.Bioengineered · 2022Article
- Therapeutic application of light and electromagnetic fields to reduce hyper-inflammation triggered by COVID-19.Communicative & integrative biology · 2021Article
- Meet the editor series-Massimo Vassalli.Biophysical reviews · 2021Article
- Pulsed Electromagnetic Field Stimulation in Osteogenesis and Chondrogenesis: Signaling Pathways and Therapeutic Implications.International journal of molecular sciences · 2021Review
- Altered BMP2/4 Signaling in Stem Cells and Their Niche: Different Cancers but Similar Mechanisms, the Example of Myeloid Leukemia and Breast Cancer.Frontiers in cell and developmental biology · 2021Review
- Recent Advances in Biomaterials for the Treatment of Bone Defects.Organogenesis · 2020Review
- In Vitro Production of Calcified Bone Matrix onto Wool Keratin Scaffolds via Osteogenic Factors and Electromagnetic Stimulus.Materials (Basel, Switzerland) · 2020Article
- Article
- Electromagnetic field treatment increases purinergic receptor P2X7 expression and activates its downstream Akt/GSK3β/β-catenin axis in mesenchymal stem cells under osteogenic induction.Stem cell research & therapy · 2019Article
- The NATO project: nanoparticle-based countermeasures for microgravity-induced osteoporosis.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) are considered a great promise in the repair and regeneration of bone. Considerable efforts have been oriented towards uncovering the best strategy to promote stem cells osteogenic differentiation. In previous studies, hBM-MSCs exposed to physical stimuli such as pulsed electromagnetic fields (PEMFs) or directly seeded on nanostructured titanium surfaces (TiO2) were shown to improve their differentiation to osteoblasts in osteogenic condition. In the present study, the effect of a daily PEMF-exposure on osteogenic differentiation of hBM-MSCs seeded onto nanostructured TiO2 (with clusters under 100 nm of dimension) was investigated. TiO2-seeded cells were exposed to PEMF (magnetic field intensity: 2 mT; intensity of induced electric field: 5 mV; frequency: 75 Hz) and examined in terms of cell physiology modifications and osteogenic differentiation. Results showed that PEMF exposure affected TiO2-seeded cells osteogenesis by interfering with selective calcium-related osteogenic pathways, and greatly enhanced hBM-MSCs osteogenic features such as the expression of early/late osteogenic genes and protein production (e.g., ALP, COL-I, osteocalcin and osteopontin) and ALP activity. Finally, PEMF-treated cells resulted to secrete into conditioned media higher amounts of BMP-2, DCN and COL-I than untreated cell cultures. These findings confirm once more the osteoinductive potential of PEMF, suggesting that its combination with TiO2 nanostructured surface might be a great option in bone tissue engineering applications.
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