ArticlePLoS genetics2018
An intronic enhancer of Bmp6 underlies evolved tooth gain in sticklebacks.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Pooled it
- Comparative Genomic Screening Identifies Developmental Constraint Loci Underscoring the Phenotypic Evolution of Syngnathids.Integrative zoology · 2026Article
- Craniofacial-specific transcriptomics uncovers novel genes underlying jaw divergence in dietary specialist pupfishes.Genetics · 2025Article
- Transcriptome Analysis Elucidates the Potential Key Genes Involved in Rib Development inAnimals : an open access journal from MDPI · 2024Article
- Co-option of an Astacin Metalloprotease Is Associated with an Evolutionarily Novel Feeding Morphology in a Predatory Nematode.Molecular biology and evolution · 2023Article
- Modulation of tooth regeneration through opposing responses to Wnt and BMP signals in teleosts.Development (Cambridge, England) · 2023Article
- Site pleiotropy of a stickleback Bmp6 enhancer.Developmental biology · 2022Article
- Freshwater Colonization, Adaptation, and Genomic Divergence in Threespine Stickleback.Integrative and comparative biology · 2022Article
- Review
- The ectodysplasin-A receptor is a candidate gene for lateral plate number variation in stickleback fish.G3 (Bethesda, Md.) · 2022Article
- Evolved Bmp6 enhancer alleles drive spatial shifts in gene expression during tooth development in sticklebacks.Genetics · 2021Article
- Threespine Stickleback: A Model System For Evolutionary Genomics.Annual review of genomics and human genetics · 2021Review
- Article
- Grand Challenges in Comparative Tooth Biology.Integrative and comparative biology · 2020Article
- An osmolality/salinity-responsive enhancer 1 (OSRE1) in intron 1 promotes salinity induction of tilapia glutamine synthetase.Scientific reports · 2020Article
- Transcriptomic analysis of dead end knockout testis reveals germ cell and gonadal somatic factors in Atlantic salmon.BMC genomics · 2020Article
- Dissecting Trait Variation across Species Barriers.Trends in ecology & evolution · 2019Review
- Searching for Sympatric Speciation in the Genomic Era.BioEssays : news and reviews in molecular, cellular and developmental biology · 2019Review
- Efficient CRISPR-Cas9 editing of major evolutionary loci in sticklebacks.Evolutionary ecology research · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Threespine stickleback fish offer a powerful system to dissect the genetic basis of morphological evolution in nature. Marine sticklebacks have repeatedly invaded and adapted to numerous freshwater environments throughout the Northern hemisphere. In response to new diets in freshwater habitats, changes in craniofacial morphology, including heritable increases in tooth number, have evolved in derived freshwater populations. Using a combination of quantitative genetics and genome resequencing, here we fine-mapped a quantitative trait locus (QTL) regulating evolved tooth gain to a cluster of ten QTL-associated single nucleotide variants, all within intron four of Bone Morphogenetic Protein 6 (Bmp6). Transgenic reporter assays revealed this intronic region contains a tooth enhancer. We induced mutations in Bmp6, revealing required roles for survival, growth, and tooth patterning. Transcriptional profiling of Bmp6 mutant dental tissues identified significant downregulation of a set of genes whose orthologs were previously shown to be expressed in quiescent mouse hair stem cells. Collectively these data support a model where mutations within a Bmp6 intronic tooth enhancer contribute to evolved tooth gain, and suggest that ancient shared genetic circuitry regulates the regeneration of diverse vertebrate epithelial appendages including mammalian hair and fish teeth.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.