Trial reportPloS one2018
Rapid high resolution T1 mapping as a marker of brain development: Normative ranges in key regions of interest.
Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 42 citations in OpenAlex.
- Cartesian MPnRAGE for Efficient Simultaneous Multi-Contrast and Quantitative Relaxometry Imaging.Magnetic resonance in medicine · 2026Article
- 3D quantitative MRI for cognitive performance: T1 relaxation times of the right putamen and volumes of the left hippocampus as key biomarkers.Neuroimage. Reports · 2026Article
- Mapping heterogeneous region- and tissue-specific brain ageing patterns using quantitative MRI.Brain communications · 2026Article
- Advanced Quantitative Microstructure Imaging in Autism: A Review of Methodology, Group Differences, and Associations With Developmental Outcomes.Autism research : official journal of the International Society for Autism Research · 2025Review
- Comparison of test-retest repeatability of DESPOT and 3D-QALAS for TQuantitative imaging in medicine and surgery · 2025Article
- Synthetic MR: Clinical applications in neuroradiology.Neuroradiology · 2025Review
- Accelerated model-based T1, T2* and proton density mapping using a Bayesian approach with automatic hyperparameter estimation.Magnetic resonance in medicine · 2025Article
- Quantitative TImaging neuroscience (Cambridge, Mass.) · 2025Article
- Fast and reliable quantitative measures of white matter development with magnetic resonance fingerprinting.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Development of Myelin Growth Charts of the White Matter Using T1 Relaxometry.AJNR. American journal of neuroradiology · 2024Article
- Whole-brain mapping of increased manganese levels in welders and its association with exposure and motor function.NeuroImage · 2024Article
- Reproducibility of quantitative ADC, T1, and T2 measurement on the cerebral cortex: Utility of whole brain echo-planar DWI with compressed SENSE (EPICS-DWI): A pilot study.European journal of radiology open · 2023Article
- Corpus callosum in children with neurodevelopmental delay: MRI standard qualitative assessment versus automatic quantitative analysis.European radiology experimental · 2023Article
- Brainstem atrophy in dementia with Lewy bodies compared with progressive supranuclear palsy and Parkinson's disease on MRI.BMC neurology · 2023Article
- In vivo TMagnetic resonance in medicine · 2023Article
- First clinical application of a novel T1 mapping of the whole brain.The neuroradiology journal · 2022Article
- High Periventricular T1 Relaxation Times Predict Gait Improvement After Spinal Tap in Patients with Idiopathic Normal Pressure Hydrocephalus.Clinical neuroradiology · 2022Article
- Longitudinal assessment of early-life white matter development with quantitative relaxometry in nonhuman primates.NeuroImage · 2022Article
- White matter myelination during early infancy is linked to spatial gradients and myelin content at birth.Nature communications · 2022Article
- T2-Pseudonormalization and Microstructural Characterization in Advanced Stages of Late-infantile Metachromatic Leukodystrophy.Clinical neuroradiology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe studied in a clinical setting the age dependent T1 relaxation time as a marker of normal late brain maturation and compared it to conventional techniques, namely the apparent diffusion coefficient (ADC). MATERIALS AND
methodsForty-two healthy subjects ranging from ages 1 year to 20 years were included in our study. T1 brain maps in which the intensity of each pixel corresponded to T1 relaxation times were generated based on MR imaging data acquired using a MP2RAGE sequence. During the same session, diffusion tensor imaging data was collected. T1 relaxation times and ADC in white matter and grey matter were measured in seven clinically relevant regions of interest and were correlated to subjects' age.
resultsIn the basal ganglia, there was a small, yet significant, decrease in T1 relaxation time (-0.45 ≤R≤-0.59, p<10-2) and ADC (-0.60≤R≤-0.65, p<10-4) as a function of age. In the frontal and parietal white matter, there was a significant decrease in T1 relaxation time (-0.62≤R≤-0.68, p<10-4) and ADC (-0.81≤R≤-0.85, p<10-4) as a function of age. T1 relaxation time changes in the corpus callosum and internal capsule were less relevant for this age range. There was no significant difference between the correlation of T1 relaxation time and ADC with respect to age (p-value = 0.39). The correlation between T1 relaxation and ADC is strong in the white matter but only moderate in basal ganglia over this age period.
conclusionsT1 relaxation time is a marker of brain maturation or myelination during late brain development. Between the age of 1 and 20 years, T1 relaxation time decreases as a function of age in the white matter and basal ganglia. The greatest changes occur in frontal and parietal white matter. These regions are known to mature in the final stage of development and are mainly composed of association circuits. Age-correlation is not significantly different between T1 relaxation time and ADC. Therefore, T1 relaxation time does not appear to be a superior marker of brain maturation than ADC but may be considered as complementary owing the intrinsic differences in bio-physical sensitivity. This work may serve as normative ranges in clinical imaging routines.
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