ArticlePloS one2018
Theoretical open-loop model of respiratory mechanics in the extremely preterm infant.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Weaning strategies for the withdrawal of non-invasive respiratory support applying continuous positive airway pressure in preterm infants: a systematic review and meta-analysis.BMJ paediatrics open · 2020Pooled it
- Thoracoabdominal asynchrony in a virtual preterm infant: computational modeling and analysis.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- A Novel Strategy to Fit and Validate Physiological Models: A Case Study of a Cardiorespiratory Model for Simulation of Incremental Aerobic Exercise.Diagnostics (Basel, Switzerland) · 2023Article
- An enhanced respiratory mechanics model based on double-exponential and fractional calculus.Frontiers in physiology · 2023Article
- Proposed cardio-pulmonary model to investigate the effects of COVID-19 on the cardiovascular system.Heliyon · 2023Article
- Model-Base Estimation of Non-Invasive Ventilation Weaning of Preterm Infants Exposed to Osteopathic Manipulative Treatment: A Propensity-Score-Matched Cohort Study.Healthcare (Basel, Switzerland) · 2022Article
- A Damaged-Informed Lung Ventilator Model for Ventilator Waveforms.Frontiers in physiology · 2021Article
- In silico study of airway/lung mechanics in normal human breathing.Mathematics and computers in simulation · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-invasive ventilation is increasingly used for respiratory support in preterm infants, and is associated with a lower risk of chronic lung disease. However, this mode is often not successful in the extremely preterm infant in part due to their markedly increased chest wall compliance that does not provide enough structure against which the forces of inhalation can generate sufficient pressure. To address the continued challenge of studying treatments in this fragile population, we developed a nonlinear lumped-parameter respiratory system mechanics model of the extremely preterm infant that incorporates nonlinear lung and chest wall compliances and lung volume parameters tuned to this population. In particular we developed a novel empirical representation of progressive volume loss based on compensatory alveolar pressure increase resulting from collapsed alveoli. The model demonstrates increased rate of volume loss related to high chest wall compliance, and simulates laryngeal braking for elevation of end-expiratory lung volume and constant positive airway pressure (CPAP). The model predicts that low chest wall compliance (chest stiffening) in addition to laryngeal braking and CPAP enhance breathing and delay lung volume loss. These results motivate future data collection strategies and investigation into treatments for chest wall stiffening.
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Registered trials
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