ArticleCerebral cortex (New York, N.Y. : 1991)2018
Neurocognitive Profiles of Older Adults with Working-Memory Dysfunction.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Fronto-striatal dopamine D2 receptor availability is associated with cognitive variability in older individuals with low dopamine integrity.Scientific reports · 2021Trial
- Acute hyperglycaemia leads to altered frontal lobe brain activity and reduced working memory in type 2 diabetes.PloS one · 2021Trial
- Article
- Modeling and evaluating longitudinal brain maintenance and cognitive reserve using episodic memory, brain structure, and functional connectivity in older adults.GeroScience · 2026Article
- Increased functional integration of emotional control network across the adult lifespan.Aging brain · 2026Article
- Distinct and reproducible neurocognitive profiles in stable diffuse glioma: A data-driven approach to understanding cognitive heterogeneity.Neuro-oncology · 2025Article
- Aging-related losses in dopamine D2/3 receptor availability are linked to working-memory decline across five years.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Review
- Dedifferentiation of caudate functional organization is linked to reduced D1 dopamine receptor availability and poorer memory function in aging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Widespread fMRI BOLD Signal Overactivations during Cognitive Control in Older Adults Are Not Matched by Corresponding Increases in fPET Glucose Metabolism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- White matter lesion load determines exercise-induced dopaminergic plasticity and working memory gains in aging.Translational psychiatry · 2023Article
- Individual differences in age-related neurocognitive outcomes: within-subject assessment of memory for odors.Frontiers in aging neuroscience · 2023Article
- Time of day dependent longitudinal changes in resting-state fMRI.Frontiers in neurology · 2023Article
- Longitudinal stability in working memory and frontal activity in relation to general brain maintenance.Scientific reports · 2022Article
- Relationships between apparent cortical thickness and working memory across the lifespan - Effects of genetics and socioeconomic status.Developmental cognitive neuroscience · 2021Article
- Age differences in functional network reconfiguration with working memory training.Human brain mapping · 2021Article
- Prospective associations, longitudinal patterns of childhood socioeconomic status, and white matter organization in adulthood.Human brain mapping · 2020Article
- High long-term test-retest reliability for extrastriatalJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- The Effects of Working Memory Updating Training in Parkinson's Disease: A Feasibility and Single-Subject Study on Cognition, Movement and Functional Brain Response.Frontiers in psychology · 2020Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals differ in how they perceive, remember, and think. There is evidence for the existence of distinct subgroups that differ in cognitive performance within the older population. However, it is less clear how individual differences in cognition in old age are linked to differences in brain-based measures. We used latent-profile analysis on n-back working-memory (WM) performance to identify subgroups in a large sample of older adults (n = 181; age = 64-68 years). Our analysis identified one larger normal subgroup with higher performance (n = 113; 63%), and a second smaller subgroup (n = 55; 31%) with lower performance. The low-performing subgroup showed weaker load-dependent BOLD modulation and lower connectivity within the fronto-parietal network (FPN) as well as between FPN and striatum during n-back, along with lower FPN connectivity at rest. This group also exhibited lower FPN structural integrity, lower frontal dopamine D2 binding potential, inferior performance on offline WM tests, and a trend-level genetic predisposition for lower dopamine-system efficiency. By contrast, this group exhibited relatively intact episodic memory and associated brain measures (i.e., hippocampal volume, structural, and functional connectivity within the default-mode network). Collectively, these data provide converging evidence for the existence of a group of older adults with impaired WM functioning characterized by reduced cortico-striatal coupling and aberrant cortico-cortical integrity within FPN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.