Evidence map›Paper›PMID 29901439›Full record

ArticleeLife2018

Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at the

Qi Wang, Tae Hee Han, Peter Nguyen, Michal Jarnik, Mihaela Serpe

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Qi WangSection on Cellular Communication, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Tae Hee HanSection on Cellular Communication, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Peter NguyenSection on Cellular Communication, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Michal JarnikSection on Intracellular Protein Trafficking, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Mihaela SerpeSection on Cellular Communication, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.ORCID http://orcid.org/0000-0002-9205-8589
National Institutes of Health · US

Funding

Mechanisms of synapse developmentZIAHD008914 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SERPE, MIHAELA · 2011 to 2025
$16.4M
Modulation of TGF-beta signalingZIAHD008869 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SERPE, MIHAELA · 2009 to 2025
$8.0M
NIH HHS Z01 HD008869NIH HHS Z01 HD008914
6 · The paper itself

Abstract

Assembly, maintenance and function of synaptic junctions depend on extracellular matrix (ECM) proteins and their receptors. Here we report that Tenectin (Tnc), a Mucin-type protein with RGD motifs, is an ECM component required for the structural and functional integrity of synaptic specializations at the neuromuscular junction (NMJ) in

Indexed as

AnimalsAnimals, Genetically ModifiedCell LineDrosophila melanogasterDrosophila ProteinsExtracellular Matrix ProteinsIntegrin alpha ChainsMicroscopy, ConfocalMotor NeuronsMultiprotein ComplexesMuscle, StriatedNeuromuscular JunctionSpectrinSynapsesSynaptic TransmissionSynaptosomesDrosophila ProteinsExtracellular Matrix Proteinsif protein, DrosophilaIntegrin alpha ChainsMultiprotein ComplexesSpectrinTnc protein, Drosophilacell biologyD. melanogasterextracellular matrixintegrinneuromuscular junctionneurosciencesynaptic terminals

Identifiers

PMID29901439
PMCPMC6040883
OpenAlexW2808708135

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.