ArticleeLife2018
Principal cells of the brainstem's interaural sound level detector are temporal differentiators rather than integrators.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 77 citations in OpenAlex.
- Infant Cortical Tracking of Speech Shows Emerging Spatial Release from Masking in the First Year of Life.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network.Nature reviews. Neuroscience · 2026Review
- GABA corelease guides the functional maturation of glycinergic synapses in an auditory sound localization circuit.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Infant cortical tracking of speech shows emerging spatial release from masking in the first year of life.bioRxiv : the preprint server for biology · 2026Article
- Asymmetric temporal envelope encoding: Lateralization with varying envelope shape and spectral mismatch.The Journal of the Acoustical Society of America · 2025Article
- Developmental auditory deprivation in one ear impairs brainstem binaural processing and reduces spatial hearing acuity.PLoS biology · 2025Article
- Precise spike-timing information in the brainstem is well aligned with the needs of communication and the perception of environmental sounds.PLoS biology · 2025Article
- Inferring synaptic transmission from the stochastic dynamics of the quantal content: An analytical approach.PLoS computational biology · 2025Article
- Synaptic Drive onto Inhibitory and Excitatory Principal Neurons of the Mouse Lateral Superior Olive.eNeuro · 2025Article
- Distinct cell classes in the superior paraolivary nucleus (SPN) region in the gerbil auditory brainstem revealed by in vivo physiological and anatomical characterization.Hearing research · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Molecular and functional profiling of cell diversity and identity in the lateral superior olive, an auditory brainstem center with ascending and descending projections.Frontiers in cellular neuroscience · 2024Article
- Bilateral and symmetric glycinergic and glutamatergic projections from the LSO to the IC in the CBA/CaH mouse.Frontiers in neural circuits · 2024Article
- Article
- Tonotopic distribution and inferior colliculus projection pattern of inhibitory and excitatory cell types in the lateral superior olive of mice.The Journal of comparative neurology · 2023Article
- Organization of orbitofrontal-auditory pathways in the Mongolian gerbil.The Journal of comparative neurology · 2023Article
- Interaural frequency mismatch jointly modulates neural brainstem binaural interaction and behavioral interaural time difference sensitivity in humans.Hearing research · 2023Article
- The continued importance of comparative auditory research to modern scientific discovery.Hearing research · 2023Review
- Principal neuron diversity in the murine lateral superior olive supports multiple sound localization strategies and segregation of information in higher processing centers.Communications biology · 2023Article
- Interaural time difference sensitivity under binaural cochlear implant stimulation persists at high pulse rates up to 900 pps.Scientific reports · 2023Article
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3 authors at 3 institutions in 2 countries.
Funding
Abstract
The brainstem's lateral superior olive (LSO) is thought to be crucial for localizing high-frequency sounds by coding interaural sound level differences (ILD). Its neurons weigh contralateral inhibition against ipsilateral excitation, making their firing rate a function of the azimuthal position of a sound source. Since the very first in vivo recordings, LSO principal neurons have been reported to give sustained and temporally integrating 'chopper' responses to sustained sounds. Neurons with transient responses were observed but largely ignored and even considered a sign of pathology. Using the Mongolian gerbil as a model system, we have obtained the first in vivo patch clamp recordings from labeled LSO neurons and find that principal LSO neurons, the most numerous projection neurons of this nucleus, only respond at sound onset and show fast membrane features suggesting an importance for timing. These results provide a new framework to interpret previously puzzling features of this circuit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.