ArticleDiabetes technology & therapeutics2018
Continuous Glucose Monitoring, Glycemic Variability, and Excessive Fetal Growth in Pregnancies Complicated by Type 1 Diabetes.
Article in Diabetes technology & therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Exploratory Analysis of Glycemic Control and Variability Over Gestation Among Pregnant Women with Type 1 Diabetes.Diabetes technology & therapeutics · 2021Trial
- Diabetes Monitoring in Pregnant Women with Type 1 Diabetes: Capillary Blood Glucose or Interstitial Fluid Glucose? A Case Control Study.Nutrition and metabolic insights · 2026Article
- Continuous Glucose Monitoring Metrics for Pregnancies Complicated by Diabetes: Critical Appraisal of Current Evidence.Journal of diabetes science and technology · 2024Review
- Continuous glucose monitoring metrics in pregnancy with type 1 diabetes mellitus.World journal of methodology · 2024Review
- Continuous Glucose Monitoring Metrics in High-Risk Pregnant Women with Type 2 Diabetes.Diabetes technology & therapeutics · 2023Observational
- Ambulatory Glucose Profile Changes During Pregnancy in Women With Type 1 Diabetes Using Intermittently Scanned Continuous Glucose Monitoring Empowered by Personalized Education.Diabetes spectrum : a publication of the American Diabetes Association · 2023Article
- Glycemic Variability in Type 1 Diabetes Mellitus Pregnancies-Novel Parameters in Predicting Large-for-Gestational-Age Neonates: A Prospective Cohort Study.Biomedicines · 2022Article
- Association Between HbA1c Levels on Adverse Pregnancy Outcomes During Pregnancy in Patients With Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2022Observational
- Assessing Glycemic Control Using CGM for Women with Diabetes in Pregnancy.Current diabetes reports · 2021Review
- Identification of maternal continuous glucose monitoring metrics related to newborn birth weight in pregnant women with gestational diabetes.Endocrine · 2021Article
- Time in Range in Pregnancy: Is There a Role?Diabetes spectrum : a publication of the American Diabetes Association · 2021Article
- Novel Biochemical Markers of Glycemia to Predict Pregnancy Outcomes in Women With Type 1 Diabetes.Diabetes care · 2021Article
- Dietary intakes of women with Type 1 diabetes before and during pregnancy: a pre-specified secondary subgroup analysis among CONCEPTT participants.Diabetic medicine : a journal of the British Diabetic Association · 2020Article
- Pregnancy in Patients with Type One Diabetes Mellitus Treated with Continuous Subcutaneous Insulin Infusion-Preconception Basal Insulin Dose as a Potential Risk Factor for Fetal Overgrowth?International journal of environmental research and public health · 2020Article
- Continuous glucose monitoring in pregnant women with type 1 diabetes: an observational cohort study of 186 pregnancies.Diabetologia · 2019Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundTo examine trimester-specific associations among glycemic variability, fetal growth, and birthweight in pregnancies with type 1 diabetes mellitus (Type 1 DM).
methodsIn this retrospective cohort study of 41 pregnant women with Type 1 DM, we used continuous glucose monitoring (CGM) data to calculate glycemic variability (coefficient of variation of glucose) over a 7-day interval in each trimester. Clinical data, including fetal biometry, birthweight, and perinatal complications, were extracted from medical records.
resultsWomen maintained good glycemic control during pregnancy, with mean HbA1c in the first, second, and third trimester 6.5%, 6.1%, and 6.4%, respectively. Sixty-three percent of infants were large for gestational age (LGA). Estimated fetal weight percentile (EFW%ile) and abdominal circumference percentile (AC%ile) increased during pregnancy, consistent with accelerated prenatal growth. Correlations between trimester-specific glycemic variability and EFW, AC, and birthweight were not statistically significant. After maternal age adjustment, glycemic variability was not associated with birthweight for any trimester (adj. β for first trimester: -38.46, 95% CI: -98.58 to 21.66; adj. β for second trimester: -12.20, 95% CI: -51.47 to 27.06; adj. β for third trimester: -26.26, 95% CI: -79.52 to 27.00).
conclusionsThe occurrence of LGA remains very high in contemporary U.S. women with Type 1 DM, despite the use of CGM and overall good glycemic control. Neither HbA1c nor glycemic variability predicted fetal overgrowth or birthweight. Since LGA is a key driver of maternal and newborn complications in pregnancies with Type 1 DM, our data emphasize the importance of investigating both glucose-dependent and glucose-independent underlying mechanisms.
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