ArticleMolecular medicine reports2018
Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- In vitro cytotoxicity of medicinal plants used in prostate cancer management in Africa: a systematic review.Tropical medicine and health · 2026Review
- Predicting the impact of climate change on the habitat suitability and phytochemical quality of Salvia multicaulis Vahl.BMC plant biology · 2025Article
- Determination of bioactive and anti-inflammatory molecules of Thymbra spicata L. from Mardin by GC-MS and LC-Orbitrap HRMS: a DFT, molecular docking, ADMET, biological target and activity study.BMC complementary medicine and therapies · 2025Article
- Exploring the Anticancer Potential ofPlants (Basel, Switzerland) · 2023Article
- Assessment of Cytotoxic and Apoptotic Effects ofIranian journal of pharmaceutical research : IJPR · 2021Article
- Health-Promoting Effects ofAntioxidants (Basel, Switzerland) · 2020Review
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- Proapoptotic Activity ofMolecules (Basel, Switzerland) · 2020Article
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Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiogenesis plays a crucial role in malignant tumor progression and development. The present study aimed to identify lead plants with selective anti-angiogenic properties. A total of 26 methanolic extracts obtained from 18 plants growing in Saudi Arabia and Jordan that belong to the Lamiaceae family were screened for their cytotoxic and anti-angiogenic activities using MTT and rat aortic ring assays, respectively. Four novel extracts of Thymbra capitata (L.) Cav., Phlomis viscosa Poir, Salvia samuelssonii Rech.f., and Premna resinosa (Hochst.) Schauer were identified for their selective anti-angiogenic effects. These extracts did not exhibit cytotoxic effects on human endothelial cells (EA.hy926) indicating the involvement of indirect anti-angiogenic mechanisms. The active extracts are potential candidates for further phytochemical and mechanistic studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.