Evidence map›Paper›PMID 29901188›Full record

ArticleMolecular medicine reports2018

Differences in the expression profiles of claudin proteins in human gastric carcinoma compared with non‑neoplastic mucosa.

Luoluo Yang, Xun Sun, Xiangwei Meng

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  11. Targeting claudins in cancer: diagnosis, prognosis and therapy.American journal of cancer research · 2021
    Review
  12. Article
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  15. Review
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  17. Article
  18. Regulation of Proliferation and Epithelial-to-Mesenchymal Transition (EMT) of Gastric Cancer by ZEB1 via Modulating Wnt5a and Related Mechanisms.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  19. Colquhounia Root Tablet Protects Rat Pulmonary Microvascular Endothelial Cells against TNF-Evidence-based complementary and alternative medicine : eCAM · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Luoluo YangDepartment of Gastroenterology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Xun SunDepartment of Pathology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Xiangwei MengDepartment of Gastroenterology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Jilin University · CNFirst Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous genetic alterations associated with cancer progression have the potential to serve as biomarkers for the early diagnosis of cancer. Numerous studies have suggested that claudin proteins, which are the primary components of tight junction structures, are associated with the regulation of cell polarity and cell differentiation. To investigate the expression profiles of the tight junction proteins claudin‑2, ‑5, ‑7 and ‑8 in gastric carcinoma, immunohistochemical analysis, western blotting and reverse transcription‑quantitative polymerase chain reaction analysis was used to detect the expression profiles of these claudin proteins in gastric carcinoma tissues and in homologous non‑neoplastic mucosal tissues. According to the present study, the expression levels of claudin‑7 and claudin‑8 were downregulated, while the expression of claudin‑5 was upregulated in gastric carcinoma tissues compared with in non‑neoplastic mucosal tissues. Additionally, no notable difference was observed between claudin‑2 expression in gastric carcinoma tissues and non‑neoplastic mucosae. Correlations between claudin‑7 and ‑8 expression and lymphatic metastasis in gastric carcinoma tissues were additionally reported. In summary, the present study revealed the distinct expression profiles of claudin‑5, ‑7 and ‑8 in non‑neoplastic mucosal tissues and gastric carcinoma tissues. Furthermore, the expression of these claudin proteins was highly associated with metastatic progression and prognosis in patients with gastric carcinoma, and had predictive value for the metastasis and survival of patients with gastric carcinoma.

Indexed as

Gene Expression ProfilingGene Expression Regulation, NeoplasticAdultAgedAged, 80 and overClaudinsFemaleGastric MucosaHumansLymphatic MetastasisMaleMiddle AgedNeoplasm ProteinsStomach NeoplasmsClaudinsNeoplasm Proteins

Identifiers

PMID29901188
PMCPMC6072183
OpenAlexW2807561648

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.